Document Detail


Does nimodipine influence sex difference in outcome after aneurysmal subarachnoid haemorrhage?
MedLine Citation:
PMID:  8955435     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Before nimodipine was introduced as a standard treatment in patients with aneurysmal subarachnoid haemorrhage (SAH) females had a significantly poorer outcome which might be due to a higher frequency of delayed cerebral ischaemia (DCI). We evaluated the overall outcome with regard to gender in 188 consecutive patients with a verified ruptured intracranial aneurysm treated with nimodipine. The only significant differences concerning prognostic factors between the sexes were a higher frequency of SAH at the primary CT in female (p < 0.05) and a higher frequency of middle cerebral artery aneurysms in females (p < 0.01). These factors affect the outcome in females unfavourably. However, contrary to previous studies, we found no difference in overall outcome after three months between the sexes in this clinical material. Our observation can be explained by a positive effect of nimodipine on DCI.
Authors:
J Hauerberg; J Rosenørn; E B Skriver
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta neurochirurgica     Volume:  138     ISSN:  0001-6268     ISO Abbreviation:  Acta Neurochir (Wien)     Publication Date:  1996  
Date Detail:
Created Date:  1997-03-18     Completed Date:  1997-03-18     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0151000     Medline TA:  Acta Neurochir (Wien)     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  1168-71     Citation Subset:  IM    
Affiliation:
University Clinic of Neurosurgery, Copenhagen County Hospital, Glostrup, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adolescent
Adult
Aged
Aneurysm, Ruptured / diagnosis,  drug therapy*,  mortality
Brain Damage, Chronic / diagnosis,  mortality
Brain Ischemia / diagnosis,  drug therapy,  mortality
Calcium Channel Blockers / adverse effects,  therapeutic use*
Female
Humans
Infusions, Intravenous
Intracranial Aneurysm / diagnosis,  drug therapy*,  mortality
Male
Middle Aged
Nimodipine / adverse effects,  therapeutic use*
Sex Factors
Subarachnoid Hemorrhage / diagnosis,  drug therapy*,  mortality
Survival Rate
Treatment Outcome
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers; 66085-59-4/Nimodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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