Document Detail


Does neonatal and infant neurodevelopmental morbidity of multiples and singletons differ?
MedLine Citation:
PMID:  20673654     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mortality and morbidity of twins may differ from that in singletons because of the greater incidence of intrauterine growth restriction, higher rates of prematurity, zygosity and even from the presence of a same age sibling during childhood. Early outcomes appear poorer for twins, but any differences are lost when corrections for gestation and growth restriction are made. Some studies show poorer cognitive outcomes for twins; larger and more recent studies show small but significant differences even when confounders are taken into account. Cerebral palsy rates are considerably higher in twins, especially with the death of a co-twin. Behavioural outcomes are broadly similar in twins and singletons, with growth and gestation being more important determinants than plurality. Psychiatric symptoms again are broadly similar, although there appears to be a reduced risk of suicide in twins.
Authors:
Richard William Ingram Cooke
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-07-29
Journal Detail:
Title:  Seminars in fetal & neonatal medicine     Volume:  15     ISSN:  1878-0946     ISO Abbreviation:  Semin Fetal Neonatal Med     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-10-18     Completed Date:  2011-02-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101240003     Medline TA:  Semin Fetal Neonatal Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  362-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2010. Published by Elsevier Ltd.
Affiliation:
School of Reproductive and Developmental Medicine, University of Liverpool, Liverpool Women's Hospital, Crown Street, Liverpool L8 7SS, UK. mc19@liv.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Brain / embryology,  growth & development
Cerebral Palsy / epidemiology*
Child Development
Cognition*
Female
Fetal Development
Humans
Infant, Newborn
Mental Disorders / epidemiology*
Pregnancy
Pregnancy Outcome
Pregnancy, Multiple*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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