Document Detail

Does nasal nitric oxide come from the sinuses?
MedLine Citation:
PMID:  10461256     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to assess nitric oxide (NO) output by the nose and sinuses. METHOD: In one volunteer, the osteomeatal complex and sphenoethmoidal recess were occluded to isolate the nose from the sinuses. The antrum and frontal sinus were each punctured by two catheters and irrigated with air at constant flow. Nitric oxide output and its rate of accumulation in the absence of air flow were measured in each sinus and in the adjacent nasal cavity. RESULTS: Prior to ostial occlusion, NO output in the nose was 96 nL/min. It decreased by 12% after blockage of all of the ostia. In the isolated sinuses, it was 190 nL/min (antrum) and 68 nL/min (frontal). After 5 minutes stagnation; NO concentration [NO] rose in the occluded sinuses to 24,700 nL/L in the antrum and 22,300 nL/L in the frontal sinus. In the nose, it increased to 29,000 nL/L. When the period of stagnation was prolonged in the frontal sinus, the [NO] reached a plateau. NO output and accumulation were not altered in the nose or either sinus by opening their ostia. In the antrum and frontal sinus, lidocaine reduced NO output and the rate of NO accumulation, but not in the nose. CONCLUSIONS: In this volunteer, 88% of nasal NO was derived from the nose itself. Nitric oxide exchange between the frontal sinus, antrum, and nose was negligible. In the absence of air flow, [NO] rose to a plateau in the nose and frontal sinus. Lidocaine inhibited NO output in the sinuses but not the nose.
J S Haight; P G Djupesland; W Qjan; J M Chatkin; H Furlott; J Irish; I Witterick; P McClean; R S Fenton; V Hoffstein; N Zamel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of otolaryngology     Volume:  28     ISSN:  0381-6605     ISO Abbreviation:  J Otolaryngol     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-10-22     Completed Date:  1999-10-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7610513     Medline TA:  J Otolaryngol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  197-204     Citation Subset:  IM    
Phil Cole Laboratories, University of Toronto, Ontario.
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MeSH Terms
Chemiluminescent Measurements
Middle Aged
Nasal Mucosa / metabolism*
Nitric Oxide / analysis,  metabolism*
Paranasal Sinuses / metabolism*
Reg. No./Substance:
10102-43-9/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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