Document Detail


Does myocardial perfusion scintigraphy demonstrate clinical usefulness in patients with markedly positive exercise tests? An assessment of the method in a high-risk subset.
MedLine Citation:
PMID:  8154418     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To evaluate the clinical utility of perfusion scintigraphy in patients with markedly positive exercise ECGs, we studied 94 consecutive patients with markedly positive exercise ECGs; 74 of them were also studied with scintigraphy. Patients undergoing scintigraphy had an intermediate pretest likelihood of coronary disease and were divided into two groups: those with reversible defects involving one complete area or aspects of multiple vascular areas (group 1, 38 patients), and those with normal scintigrams and reversible defects in a limited aspect of one vascular area, isolated fixed defects, or both (group 2, 36 patients). Among all demographic and exercise variables, only a hypotensive or blunted blood pressure response and scintigraphic lung uptake or cavitary dilation, although insensitive, were more frequent in group 1 (all p < 0.05). All 36 patients in group 1 and 14 of 18 in group 2 who underwent coronary angiography had significant coronary lesions; 31 in group 1 but only seven in group 2 had multivessel disease (p < 0.05). Subsequently 32 patients in group 1 had revascularization compared with only two patients in group 2. Only one cardiac event was noted among 34 patients in group 2 who were followed for a mean of 38 months while they were being treated medically. However, four of nine patients in group 1 initially treated medically required late revascularization because of clinical progression of disease, and one patient died (p < 0.05). Compared with patients having scintigraphy, patients not imaged had a higher pretest likelihood of coronary disease, a higher incidence of angina, unstable angina, and induced angina, with a lower exercise time and time to ST depression (p < 0.05). All underwent angiography, and 16 had multivessel disease. Not all patients with markedly positive exercise ECGs were at similarly high coronary risk. Some with high-risk coronary anatomy were identified without the use of scintigraphy. In others, where diagnosis and prognosis were less clear, scintigraphy aided in the diagnosis and accurately identified a low-risk subgroup as did no other parameter.
Authors:
R Krishnan; J Lu; M W Dae; E H Botvinick
Related Documents :
10499688 - Serial use of bedside ckmb/myoglobin device to detect acute myocardial infarction in em...
16689138 - Role of exercise tolerance test (ett) and gated single photon emission computed tomogra...
19070378 - Long-term prognosis of patients with cardiac syndrome x.
8102238 - Bilateral mammary grafting. clinical, functional and angiographic assessment in 400 con...
17725748 - Sustained polymorphic arrhythmias induced by programmed ventricular stimulation have pr...
20843908 - Comparative analysis of disease activity measures, use of biologic agents, body mass in...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American heart journal     Volume:  127     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-05-12     Completed Date:  1994-05-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  804-16     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, University of California, San Francisco.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Analysis of Variance
Coronary Angiography
Coronary Disease / diagnosis,  radionuclide imaging*
Electrocardiography
Exercise Test*
Female
Heart / radionuclide imaging
Humans
Logistic Models
Male
Middle Aged
Retrospective Studies
Risk Factors
Thallium Radioisotopes / diagnostic use
Tomography, Emission-Computed, Single-Photon
Chemical
Reg. No./Substance:
0/Thallium Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Prevalence of right ventricular perfusion defects after inferior myocardial infarction assessed by l...
Next Document:  Effects of aminophylline on cardiac function and regional myocardial perfusion: implications regardi...