| Does a myelomeningocele sac compared to no sac result in decreased postnatal leg function following maternal fetal surgery for spina bifida aperta? | |
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MedLine Citation:
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PMID: 17556822 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: A fetus with large sac S1 myelomeningocele (MMC) but bilateral talipes prompted the question, 'Does the presence or size of an MMC sac affect postnatal leg function?' STUDY DESIGN: An MMC database with prenatal, birth, and a minimum of 1-year follow-up evaluation was reviewed. All fetuses had in-utero MMC repair at 20 + 0 to 25 + 6 weeks at a single institution. Fifty-four fetuses had prenatal evaluation, with 48 children completing a birth and a 1-year evaluation of leg function. RESULTS: An MMC sac was present in 38/54 (70%) of fetuses evaluated in-utero and had been present in 35/48 (73%) of children evaluated at 1 year of age. Although leg function evaluated at 1 year was better than expected in the 'no sac' group (p = 0.059), this did not reach statistical significance. CONCLUSION: The presence of an MMC sac may increase postnatal lower limb morbidity. |
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Authors:
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R Douglas Wilson; Mark P Johnson; Michael Bebbington; Alan W Flake; Holly L Hedrick; Leslie N Sutton; N Scott Adzick |
Publication Detail:
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Type: Comparative Study; Journal Article Date: 2007-06-05 |
Journal Detail:
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Title: Fetal diagnosis and therapy Volume: 22 ISSN: 1421-9964 ISO Abbreviation: Fetal. Diagn. Ther. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-08-16 Completed Date: 2007-09-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107463 Medline TA: Fetal Diagn Ther Country: Switzerland |
Other Details:
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Languages: eng Pagination: 348-51 Citation Subset: IM |
Copyright Information:
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Copyright 2007 S. Karger AG, Basel. |
Affiliation:
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Department of Surgery and Obstetrics and Gynecology, Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4399, USA. wilsonrd@email.chop.edu |
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| MeSH Terms | |
Descriptor/Qualifier:
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Cohort Studies Female Fetal Therapies / methods Follow-Up Studies Humans Infant Infant, Newborn Infant, Newborn, Diseases* / diagnosis, physiopathology Leg / pathology, physiology* Meningomyelocele / complications, diagnosis, surgery* Pregnancy Retrospective Studies Spina Bifida Cystica / complications, diagnosis, surgery* |
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