Document Detail


Does mild valvular aortic stenosis progress during childhood?
MedLine Citation:
PMID:  16480005     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND AIM OF THE STUDY: An increased gradient in congenital valvular aortic stenosis (AS) during follow up remains the subject of controversy, and may determine a need for treatment in pediatric patients. It is hypothesized that a valvular gradient < 40 mmHg indicates a stable tendency at follow up for congenital valvular AS. METHODS: Twenty-five cases with valvular AS, isolated but not treated, were followed for eight years (range: 0.14-18.8 years). Clinical and complementary tests (electrocardiography, X-radiography) were undertaken. The gradient anatomy and function were measured using M-mode, two-dimensional, and Doppler echocardiography. RESULTS: No significant changes were noted in symptoms or at physical examination. Signs of cardiac enlargement were decreased (p < 0.001), and the functional status and gradient remained stable during the follow up period (mean difference 2.38 mmHg; p = 0.74). The relationship between gradient and age showed a slowly increasing trend (r = 0.20). CONCLUSION: The trend in gradient confirmed the stable nature of mild AS. Patients in whom gradients were < 40 mmHg at the time of diagnosis remained stable and required no treatment. Subsequent follow up control and clinical management of these patients may be performed at intervals of two years, or more.
Authors:
Julio Ardura; Carmen Gonzalez; Jesus Andres
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of heart valve disease     Volume:  15     ISSN:  0966-8519     ISO Abbreviation:  J. Heart Valve Dis.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-02-16     Completed Date:  2006-09-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9312096     Medline TA:  J Heart Valve Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  1-4     Citation Subset:  IM    
Affiliation:
Pediatric Cardiology, University Hospital, Facultad de Medicina, Valladolid, Spain. ardura@ped.uva.es
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Age Factors
Aortic Valve Insufficiency / congenital,  diagnosis,  pathology,  physiopathology
Aortic Valve Stenosis / congenital,  diagnosis,  pathology*,  physiopathology*
Child
Child, Preschool
Disease Progression
Echocardiography, Doppler
Electrocardiography
Female
Follow-Up Studies
Heart Rate
Humans
Infant
Male
Prospective Studies
Radiography, Thoracic
Severity of Illness Index
Stroke Volume
Ventricular Function, Left

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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