Document Detail


Does the method of treatment affect the outcome in soft-tissue sarcomas of the adductor compartment?
MedLine Citation:
PMID:  17075094     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have investigated the significance of the method of treatment on the oncological and functional outcomes and on the complications in 184 patients with soft-tissue sarcomas of the adductor compartment managed at three international centres. The overall survival at five years was 65% and was related to the grade at diagnosis and the size of the tumour. There was no difference in overall survival between the three centres. There was, however, a significant difference in local control with a rate of 28% in Centre 1 compared with 10% in Centre 2 and 5% in Centre 3. The overall mean functional score using the Toronto Extremity Salvage Score in 70 patients was 77% but was significantly worse in patients with wound complications or high-grade tumours. The scores were not affected by the timing of radiotherapy or the use of muscle flaps. This large series of soft-tissue sarcomas of the adductor compartment has shown that factors influencing survival do not vary across the international boundaries studied, but that methods of treatment affect complications, local recurrence and function.
Authors:
A Pradhan; Y C Cheung; R J Grimer; A Abudu; D Peake; P C Ferguson; A M Griffin; J S Wunder; B O'Sullivan; R Hugate; F H Sim
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  The Journal of bone and joint surgery. British volume     Volume:  88     ISSN:  0301-620X     ISO Abbreviation:  J Bone Joint Surg Br     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-31     Completed Date:  2006-12-19     Revised Date:  2010-11-10    
Medline Journal Info:
Nlm Unique ID:  0375355     Medline TA:  J Bone Joint Surg Br     Country:  England    
Other Details:
Languages:  eng     Pagination:  1480-6     Citation Subset:  AIM; IM    
Affiliation:
Royal Orthopaedic Hospital Oncology Service, Birmingham, England.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Combined Modality Therapy / methods
Female
Humans
Male
Middle Aged
Neoplasm Recurrence, Local
Postoperative Care / methods
Postoperative Complications
Preoperative Care / methods
Retrospective Studies
Sarcoma / mortality,  radiotherapy,  surgery*
Soft Tissue Neoplasms / mortality,  radiotherapy,  surgery*
Survival Analysis
Thigh / surgery
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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