Document Detail

Does metformin augment the ovulation inducing effects of clomiphene in non-obese women with polycystic ovary syndrome?
MedLine Citation:
PMID:  19552097     Owner:  NLM     Status:  MEDLINE    
To decide if metformin augments clomiphene response for ovulation induction in non-obese women with polycystic ovary syndrome, a prospective randomised placebo-controlled trial was undertaken among 27 patients, who were found eligible for this study following clinical assessment and basic investigations. Women with polycystic ovary syndrome, even when non-obese, has increased insulin-resistance and do not respond favourably when treated with clomiphene for ovulation induction. The hypothesis is that by improving insulin- resistance and thus reversing from hyperinsulinaemia towards normal insulin secretion will enhance the responsiveness of these women to ovulation inducing effects of clomiphene. In the metformin group there were 15 patients who were given metformin 500mg orally 8 hourly daily for initial 3 months whereas in the placebo group there were 12 patients who were given folic acid (as placebo) 5mg orally once daily for initial 3 months. Thereafter, all the 27 patients in both groups were treated with clomiphene 50mg orally once daily from day 2 for 5 days in each month for subsequent 3 months. However, metformin and folic acid was continued in the metformin group and placebo group respectively for these subsequent 3 months when these patients were being treated with clomiphene for ovulation induction. Ovulation, as the outcome measure, was assessed by serial transvaginal ultrasound scanning from day 8/ day 9 and serum progesterone estimation on the 7th or 8th day following the ultrasound evidence of ovulation. Ovulation is taken to have occurred when serum progesterone was > or =8 ng/ml. Ovulation was noted to have occurred in 71.11% of the 45 cycles studied in 15 patients in the metformin group whereas ovulation occurred in 11.11% of the 36 cycles studied in 12 patients in the placebo group. This difference was highly statistically significant (p < 0.001) by Fisher's exact test. It can be conducted that metformin augments the ovulation inducing effects of clomiphene in non-obese women with polycystic ovary syndrome.
Kalyansree Chaudhury; Sudeshna Chaudhury; Subhankar Chowdhury
Related Documents :
16019357 - Time since menopause does not affect plasma viscosity, plasma thromboxane levels and do...
11163817 - Long-term remission of ovarian hyperandrogenism after short-term treatment with a gonad...
22544007 - Do local meteorological conditions influence skin irritation caused by transdermal riva...
17368257 - Tissue encapsulation of the proximal essure micro-insert from the uterine cavity follow...
6828277 - Single-dose ampicillin for cesarean section prophylaxis.
19858237 - The impact of different biocompatible coated cardiopulmonary bypass circuits on inflamm...
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of the Indian Medical Association     Volume:  106     ISSN:  0019-5847     ISO Abbreviation:  J Indian Med Assoc     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2009-06-25     Completed Date:  2009-07-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505608     Medline TA:  J Indian Med Assoc     Country:  India    
Other Details:
Languages:  eng     Pagination:  643-4, 646-8     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, Chittaranjan Seva Sadan, Kolkata.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Clomiphene / administration & dosage,  therapeutic use*
Fertility Agents, Female / administration & dosage,  therapeutic use*
Hypoglycemic Agents / administration & dosage,  pharmacology*
Metformin / administration & dosage,  pharmacology*
Ovulation Induction / methods*
Polycystic Ovary Syndrome / drug therapy*
Prospective Studies
Reg. No./Substance:
0/Fertility Agents, Female; 0/Hypoglycemic Agents; 657-24-9/Metformin; 911-45-5/Clomiphene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Malaria associated acute renal failure--experience from Rourkela, eastern India.
Next Document:  Short-term mortality and complications in ST elevation myocardial infarction--the Heart Hospital exp...