| Does melatonin deficiency cause the enlarged genitalia of the fragile-X syndrome? | |
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MedLine Citation:
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PMID: 3519008 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Melatonin profiles were studied in five males with cytogenetic and clinical features of the fragile-X syndrome including megalo-orchidia and macrogenitosomia. In comparison with age-matched normal controls, the fragile-X group showed lower melatonin values and a significant impairment of the nocturnal rise in this hormone. Melatonin deficiency may thus be responsible for some of the phenotypic features of this disorder. |
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Authors:
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J P O'Hare; I A O'Brien; J Arendt; P Astley; W Ratcliffe; H Andrews; R Walters; R J Corrall |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical endocrinology Volume: 24 ISSN: 0300-0664 ISO Abbreviation: Clin. Endocrinol. (Oxf) Publication Date: 1986 Mar |
Date Detail:
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Created Date: 1986-07-17 Completed Date: 1986-07-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 327-33 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Fragile X Syndrome / blood, etiology*, pathology Genitalia, Male / pathology* Humans Male Melatonin / blood, deficiency* Middle Aged Pedigree Penis / pathology Sex Chromosome Aberrations / etiology* Testis / pathology Ultrasonography |
| Chemical | |
Reg. No./Substance:
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73-31-4/Melatonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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