Document Detail

Does magnetic resonance spectroscopy identify patients with minimal hepatic encephalopathy?
MedLine Citation:
PMID:  23161187     Owner:  NLM     Status:  Publisher    
Background and purpose: The results of a few studies suggest that magnetic resonance spectroscopy of the brain could allow detection of minimal hepatic encephalopathy. The goal of this study was to assess the ability of magnetic resonance spectroscopy to differentiate between cirrhotic patients with and without minimal hepatic encephalopathy. Material and methods: Localized magnetic resonance spectroscopy was performed in the basal ganglia, occipital gray matter and frontal white matter in 46 patients with liver cirrhosis without overt encephalopathy and in 45 controls. Neurological and neuropsychological examination was performed in each participant. Results: The patients with liver cirrhosis had a decreased ratio of myoinositol to creatine in occipital gray matter and frontal white matter (mean: 0.17 ± 0.05 vs. 0.20 ± 0.04, p = 0.01 and 0.15 ± 0.05 vs. 0.19 ± 0.04, p < 0.01, respectively) and a decreased ratio of choline to creatine in occipital gray matter (mean: 0.32 ± 0.07 vs. 0.36 ± 0.08, p = 0.03). Minimal hepatic encephalopathy was diagnosed in 7 patients. Metabolite ratios did not differ significantly between patients with and without minimal hepatic encephalopathy. Metabolite ratios did not differ significantly between patients with Child-Pugh A and those with Child-Pugh B. Conclusions: Magnetic resonance spectroscopy does not allow accurate diagnosis of minimal hepatic encephalopathy. A similar profile of metabolites in the brain is observed in cirrhotic patients without cognitive impairment.
Irena Ciećko-Michalska; Tomasz Dziedzic; Robert Banyś; Magdalena Senderecka; Marek Binder; Mirosław Wyczesany; Jakub Szewczyk; Jan Wójcik; Agnieszka Słowik; Tomasz Mach
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Publication Detail:
Journal Detail:
Title:  Neurologia i neurochirurgia polska     Volume:  46     ISSN:  0028-3843     ISO Abbreviation:  Neurol. Neurochir. Pol.     Publication Date:  2012  
Date Detail:
Created Date:  2012-11-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0101265     Medline TA:  Neurol Neurochir Pol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  436-442     Citation Subset:  -    
Dr Irena Cieæko-Michalska, Department of Gastroenterology, Hepatology and Infectious Diseases, Jagiellonian University Medical College, ul. OEniadeckich 5, 31-531 Kraków, phone: +48 12 424 73 82, fax: +48 12 424 73 82, e-mail:
Vernacular Title:
Czy spektroskopia rezonansu magnetycznego identyfikuje pacjentów z minimalną encefalopatią wątrobową?
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