Document Detail

Does machine perfusion decrease ischemia reperfusion injury?
MedLine Citation:
PMID:  24950933     Owner:  NLM     Status:  Publisher    
In 1990's, use of machine perfusion for organ preservation has been abandoned because of improvement of preservation solutions, efficient without perfusion, easy to use and cheaper. Since the last 15 years, a renewed interest for machine perfusion emerged based on studies performed on preclinical model and seems to make consensus in case of expanded criteria donors or deceased after cardiac death donations. We present relevant studies highlighted the efficiency of preservation with hypothermic machine perfusion compared to static cold storage. Machines for organ preservation being in constant evolution, we also summarized recent developments included direct oxygenation of the perfusat. Machine perfusion technology also enables organ reconditioning during the last hours of preservation through a short period of perfusion on hypothermia, subnormothermia or normothermia. We present significant or low advantages for machine perfusion against ischemia reperfusion injuries regarding at least one primary parameter: risk of DFG, organ function or graft survival.
D Bon; P-O Delpech; N Chatauret; T Hauet; L Badet; B Barrou
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Publication Detail:
Journal Detail:
Title:  Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie     Volume:  24S1     ISSN:  1166-7087     ISO Abbreviation:  Prog. Urol.     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307844     Medline TA:  Prog Urol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  S44-S50     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Masson SAS. All rights reserved.
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