| Does loss of CD151 expression promote the metastasis of hypoxic colon cancer cells? | |
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MedLine Citation:
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PMID: 19088010 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intratumoral hypoxia increases invasion and metastasis through multiple mechanisms, including changes in gene expression that are mediated by hypoxia-inducible factor 1. In hypoxic colon cancer cells, hypoxia-inducible factor 1 inhibits the expression of CD151, a cell surface molecule that normally tethers epithelial cells to the basement membrane, which may promote metastasis. |
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Authors:
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Gregg L Semenza |
Publication Detail:
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Type: Comment; Journal Article |
Journal Detail:
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Title: Clinical cancer research : an official journal of the American Association for Cancer Research Volume: 14 ISSN: 1078-0432 ISO Abbreviation: Clin. Cancer Res. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-17 Completed Date: 2009-01-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9502500 Medline TA: Clin Cancer Res Country: United States |
Other Details:
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Languages: eng Pagination: 7969-70 Citation Subset: IM |
Affiliation:
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Vascular Program, Institute for Cell Engineering, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. gsemenza@jhmi.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD
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analysis* Cell Adhesion Cell Hypoxia* Colonic Neoplasms / pathology* Humans Neoplasm Invasiveness Neoplasm Metastasis |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/CD151 antigen |
| Comments/Corrections | |
Comment On:
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Clin Cancer Res. 2008 Dec 15;14(24):8043-51
[PMID:
19073968
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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