Document Detail

Does a local anaesthetic cream (EMLA) alleviate pain from heel-lancing in neonates?
MedLine Citation:
PMID:  8607303     Owner:  NLM     Status:  MEDLINE    
EMLA cream is an effective local anaesthetic agent for venipunctures in adults and children. The aim of this double-blind, randomised, and placebo-controlled study was to evaluate the effect of EMLA when heel-lancing was performed in neonates. On their third day of life, fullterm healthy infants, who underwent testing for phenylketonuria (PKU) by heel-lancing, were consecutively included in the study. One hundred and twelve neonates were allocated to eight groups according to the application time of EMLA or placebo (10 to 120 minutes). Thus in each group seven infants received active substance and seven placebo. The response to the nociceptive stimulation was assessed by studying the occurrence of a pain cry. No analgesic effect of EMLA was found. There were no adverse effects.
B A Larsson; L Jylli; H Lagercrantz; G L Olsson
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  39     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1996-05-23     Completed Date:  1996-05-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  1028-31     Citation Subset:  IM    
Department of Paediatric Anaesthesia and Intensive Care, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden.
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MeSH Terms
Anesthetics, Local / therapeutic use*
Double-Blind Method
Drug Combinations
Infant, Newborn
Lidocaine / adverse effects,  therapeutic use*
Pain / drug therapy*
Prilocaine / adverse effects,  therapeutic use*
Reg. No./Substance:
0/Anesthetics, Local; 0/Drug Combinations; 0/EMLA; 137-58-6/Lidocaine; 721-50-6/Prilocaine

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