Document Detail

Does light-to-moderate alcohol consumption during pregnancy increase the risk for renal anomalies among offspring?
MedLine Citation:
PMID:  9099786     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the association between light-to-moderate prenatal alcohol exposure and congenital renal anomalies. METHODS: Data from the population-based Atlanta Birth Defects Case-Control Study were used to examine the association between selected renal anomalies and self-reported maternal alcohol consumption during the period from 1 month before through 3 months after conception. Case infants were ascertained by a population-based birth defects registry with active case ascertainment; the case group consisted of 158 infants, born during 1968 through 1980 to metropolitan Atlanta residents, in whom these renal anomalies had been diagnosed. Two control groups were used. One had 3029 infants without birth defects, and the other had 4633 infants with birth defects exclusive of the urinary tract who were born during the same period. RESULTS: Overall, there was a moderate association between renal anomalies and moderate prenatal alcohol exposure (odds ratio, 1.5; 95% confidence interval, 1.0 to 2.3). When the renal anomalies were subclassified, moderate prenatal alcohol exposure was significantly associated only with renal agenesis or hypoplasia (odds ratio, 2.5; 95% confidence interval, 1.2 to 5.1), and within this group only infants with bilateral defects and other major anomalies in addition to renal agenesis or hypoplasia had significantly elevated risks. There were no significant associations between reported light consumption and any category of the selected renal anomalies. No conclusions could be reached for reported heavy consumption because of sparse data. Adjustments for potential confounding factors did not alter these results. CONCLUSION: This study suggests that moderate alcohol consumption during pregnancy may increase a woman's risk of giving birth to a child with renal agenesis or hypoplasia.
C A Moore; M J Khoury; Y Liu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics     Volume:  99     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1998-09-08     Completed Date:  1998-09-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E11     Citation Subset:  IM    
Birth Defects and Genetic Diseases Branch, Division of Birth Defects and Developmental Disabilities, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
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MeSH Terms
Abnormalities, Multiple / etiology
Alcohol Drinking*
Case-Control Studies
Confounding Factors (Epidemiology)
Ethanol / adverse effects*,  poisoning
Infant, Newborn
Kidney / abnormalities*
Maternal Exposure / adverse effects*,  classification
Odds Ratio
Risk Factors
Reg. No./Substance:

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