Document Detail


Does levodopa therapy delay death in Parkinson's disease? A review of the evidence.
MedLine Citation:
PMID:  7651439     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Studies examining the mortality from Parkinson's disease have been reviewed to assess the impact of levodopa therapy. These include national mortality data taken from death certificate returns, cohort studies comparing the deaths observed in a group of patients with those expected from population statistics, and case-control studies comparing deaths in patients with those in a matched control group. It is concluded that the decrease in crude mortality rate in the early 1970s in several western countries was mirrored by a decrease in observed to expected mortality rates in cohort studies over the same period. The rise in crude mortality in the late 1970s and early 1980s paralleled an increase in observed to expected mortality in cohort studies. These trends are compatible with the hypothesis that levodopa delayed the death of a cohort of frail elderly parkinsonian patients who succumbed approximately 5 years later, leading to an apparent "catch-up" increment in national mortality data. Whilst crude mortality in England and Wales does not appear to be increasing as fast as before the introduction of levodopa, recent cohort and case-control studies report mortality ratios comparable to those seen in the prelevodopa era. Further case-control studies are required to determine the position with current treatment regimens.
Authors:
C E Clarke
Related Documents :
10484149 - Bacillary hemoglobinuria in a free-ranging elk calf.
10399039 - Aspects of the epizootiology of pancreas disease in farmed atlantic salmon salmo salar ...
10214449 - Patterns of childhood mortality in three districts of north gondar administrative zone....
21467879 - Ileal perforation induced by a wire from a metal scouring pad in an infant.
10732309 - Chronic lung disease and survival in 4 tertiary neonatal units.
2722359 - Changes in mortality among cubans in the united states following an episode of unscreen...
2338179 - A longitudinal study of early leg postures of preterm infants.
11869599 - Extracorporeal membrane oxygenation for severe respiratory failure in newborn infants.
14648519 - Case report of a pressure ulcer in an infant receiving extracorporeal life support: the...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  10     ISSN:  0885-3185     ISO Abbreviation:  Mov. Disord.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-09-28     Completed Date:  1995-09-28     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  250-6     Citation Subset:  IM    
Affiliation:
Department of Neurology, Hull Royal Infirmary, England.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Case-Control Studies
Cause of Death
Death Certificates
England / epidemiology
Frail Elderly / statistics & numerical data
Humans
Levodopa / adverse effects,  therapeutic use*
Parkinson Disease / drug therapy*,  mortality
Survival Rate
Treatment Outcome
Wales / epidemiology
Chemical
Reg. No./Substance:
0/Levodopa
Comments/Corrections
Comment In:
Mov Disord. 1996 May;11(3):343-4   [PMID:  8723162 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  L-dihydroxyphenylalanine and its decarboxylase: new ideas on their neuroregulatory roles.
Next Document:  Abnormalities of tracking behavior in Parkinson's disease.