Document Detail

Does levodopa therapy delay death in Parkinson's disease? A review of the evidence.
MedLine Citation:
PMID:  7651439     Owner:  NLM     Status:  MEDLINE    
Studies examining the mortality from Parkinson's disease have been reviewed to assess the impact of levodopa therapy. These include national mortality data taken from death certificate returns, cohort studies comparing the deaths observed in a group of patients with those expected from population statistics, and case-control studies comparing deaths in patients with those in a matched control group. It is concluded that the decrease in crude mortality rate in the early 1970s in several western countries was mirrored by a decrease in observed to expected mortality rates in cohort studies over the same period. The rise in crude mortality in the late 1970s and early 1980s paralleled an increase in observed to expected mortality in cohort studies. These trends are compatible with the hypothesis that levodopa delayed the death of a cohort of frail elderly parkinsonian patients who succumbed approximately 5 years later, leading to an apparent "catch-up" increment in national mortality data. Whilst crude mortality in England and Wales does not appear to be increasing as fast as before the introduction of levodopa, recent cohort and case-control studies report mortality ratios comparable to those seen in the prelevodopa era. Further case-control studies are required to determine the position with current treatment regimens.
C E Clarke
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  10     ISSN:  0885-3185     ISO Abbreviation:  Mov. Disord.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-09-28     Completed Date:  1995-09-28     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  250-6     Citation Subset:  IM    
Department of Neurology, Hull Royal Infirmary, England.
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MeSH Terms
Case-Control Studies
Cause of Death
Death Certificates
England / epidemiology
Frail Elderly / statistics & numerical data
Levodopa / adverse effects,  therapeutic use*
Parkinson Disease / drug therapy*,  mortality
Survival Rate
Treatment Outcome
Wales / epidemiology
Reg. No./Substance:
Comment In:
Mov Disord. 1996 May;11(3):343-4   [PMID:  8723162 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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