Document Detail

Does the left atrial appendage morphology correlate with the risk of stroke in patients with atrial fibrillation? Results from a multicenter study.
MedLine Citation:
PMID:  22858289     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: This study investigated the left atrial appendage (LAA) by computed tomography (CT) and magnetic resonance imaging (MRI) to categorize different LAA morphologies and to correlate the morphology with the history of stroke/transient ischemic attack (TIA).
BACKGROUND: LAA represents one of the major sources of cardiac thrombus formation responsible for TIA/stroke in patients with atrial fibrillation (AF).
METHODS: We studied 932 patients with drug-refractory AF who were planning to undergo catheter ablation. All patients underwent cardiac CT or MRI of the LAA and were screened for history of TIA/stroke. Four different morphologies were used to categorize LAA: Cactus, Chicken Wing, Windsock, and Cauliflower.
RESULTS: CT scans of 499 patients and MRI scans of 433 patients were analyzed (age 59 ± 10 years, 79% were male, and 14% had CHADS(2) [Congestive heart failure, hypertension, Age >75, Diabetes mellitus, and prior stroke or transient ischemic attack] score ≥2). The distribution of different LAA morphologies was Cactus (278 [30%]), Chicken Wing (451 [48%]), Windsock (179 [19%]), and Cauliflower (24 [3%]). Of the 932 patients, 78 (8%) had a history of ischemic stroke or TIA. The prevalence of pre-procedure stroke/TIA in Cactus, Chicken Wing, Windsock, and Cauliflower morphologies was 12%, 4%, 10%, and 18%, respectively (p = 0.003). After controlling for CHADS2 score, gender, and AF types in a multivariable logistic model, Chicken Wing morphology was found to be 79% less likely to have a stroke/TIA history (odd ratio: 0.21, 95% confidence interval: 0.05 to 0.91, p = 0.036). In a separate multivariate model, we entered Chicken Wing as the reference group and assessed the likelihood of stroke in other groups in relation to reference. Compared with chicken wing, cactus was 4.08 times (p = 0.046), Windsock was 4.5 times (p = 0.038), and Cauliflower was 8.0 times (p = 0.056) more likely to have had a stroke/TIA.
CONCLUSIONS: Patients with Chicken Wing LAA morphology are less likely to have an embolic event even after controlling for comorbidities and CHADS2 score. If confirmed, these results could have a relevant impact on the anticoagulation management of patients with a low-intermediate risk for stroke/TIA.
Luigi Di Biase; Pasquale Santangeli; Matteo Anselmino; Prasant Mohanty; Ilaria Salvetti; Sebastiano Gili; Rodney Horton; Javier E Sanchez; Rong Bai; Sanghamitra Mohanty; Agnes Pump; Mauricio Cereceda Brantes; G Joseph Gallinghouse; J David Burkhardt; Federico Cesarani; Marco Scaglione; Andrea Natale; Fiorenzo Gaita
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  60     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-03     Completed Date:  2012-10-25     Revised Date:  2013-03-21    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  531-8     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Texas Cardiac Arrhythmia Institute at St. David's Medical Center, Austin, Texas 78705, USA.
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MeSH Terms
Atrial Appendage / pathology*
Atrial Fibrillation / epidemiology*
Imaging, Three-Dimensional
Ischemic Attack, Transient / epidemiology
Magnetic Resonance Angiography
Middle Aged
Multivariate Analysis
Risk Assessment*
Stroke / epidemiology*
Tomography, X-Ray Computed
Comment In:
J Am Coll Cardiol. 2013 Feb 12;61(6):690-1   [PMID:  23391205 ]
J Am Coll Cardiol. 2013 Feb 12;61(6):689-90   [PMID:  23391204 ]

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