Document Detail

Does lacosamide aggravate Lennox-Gastaut syndrome? Report on three consecutive cases.
MedLine Citation:
PMID:  20970386     Owner:  NLM     Status:  In-Data-Review    
Lennox-Gastaut syndrome is an intractable epileptic encephalopathy, with most patients experiencing daily seizures despite therapy with multiple antiepileptic drugs. New treatments need to be tested to define their efficacy in this syndrome. Lacosamide is a new antiepileptic drug recently approved for the treatment of partial-onset seizures. We describe three patients with Lennox-Gastaut syndrome resistant to conventional antiepileptic drugs whose seizures were aggravated by lacosamide.
Antonella Cuzzola; Edoardo Ferlazzo; Domenico Italiano; Rocco Salvatore Calabrò; Placido Bramanti; Pierre Genton
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Publication Detail:
Type:  Journal Article     Date:  2010-10-20
Journal Detail:
Title:  Epilepsy & behavior : E&B     Volume:  19     ISSN:  1525-5069     ISO Abbreviation:  Epilepsy Behav     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892858     Medline TA:  Epilepsy Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  650-1     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Hôpital Henri Gastaut, Centre Saint-Paul, Marseille, France; Division of Child Neurology and Psychiatry, University of Messina, Messina, Italy.
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