| Does ketogenic diet alter seizure sensitivity and cell loss following fluid percussion injury? | |
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MedLine Citation:
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PMID: 20863664 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Traumatic brain injury (TBI) frequently leads to epilepsy. The process of epileptogenesis - the development of that seizure state - is still poorly understood, and effective antiepileptogenic treatments have yet to be identified. The ketogenic diet (KD) has been shown to be effective as an antiepileptic therapy, but has not been extensively tested for its efficacy in preventing the development of the seizure state, and certainly not within the context of TBI-induced epileptogenesis. We have used a rat model of TBI - fluid percussion injury (FPI) - to test the hypothesis that KD treatment is antiepileptogenic and protects the brain from neuronal cell loss following TBI. Rats fed a KD had a higher seizure threshold (longer latency to flurothyl-induced seizure activity) than rats fed a standard diet (SD); this effect was seen when KD was in place at the time of seizure testing (3 and 6 weeks following FPI), but was absent when KD had been replaced by SD at time of testing. FPI caused significant hippocampal cell loss in both KD-fed and SD-fed rats; the degree of cell loss appeared to be reduced by KD treatment before FPI but not after FPI. These results are consistent with prior demonstrations that KD raises seizure threshold, but do not provide support for the hypothesis that KD administered for a limited time directly before or after FPI alters later seizure sensitivity; that is, within the limits of this model and protocol, there is no evidence for KD-induced antiepileptogenesis. |
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Authors:
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Philip A Schwartzkroin; H Jürgen Wenzel; Bruce G Lyeth; Carrie C Poon; Arthur Delance; Ken C Van; Luis Campos; Danh V Nguyen |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-09-21 |
Journal Detail:
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Title: Epilepsy research Volume: 92 ISSN: 1872-6844 ISO Abbreviation: Epilepsy Res. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-18 Completed Date: 2011-02-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8703089 Medline TA: Epilepsy Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 74-84 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Neurological Surgery, University of California, Davis, Davis, CA 95616, United States. paschwartzkroin@ucdavis.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3-Hydroxybutyric Acid
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metabolism Animals Antigens, CD11b / metabolism Brain Injuries / complications*, etiology Cell Count / methods Cell Death / drug effects, physiology Disease Models, Animal Follow-Up Studies Functional Laterality Glial Fibrillary Acidic Protein / metabolism Hippocampus / pathology* Ketogenic Diet* Male Organic Chemicals / adverse effects Percussion / adverse effects Rats Rats, Sprague-Dawley Reaction Time / physiology Seizures* / diet therapy, etiology, pathology Statistics, Nonparametric |
| Grant Support | |
ID/Acronym/Agency:
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UL1 RR024146/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD11b; 0/Glial Fibrillary Acidic Protein; 0/Organic Chemicals; 0/fluro-ethyl; 300-85-6/3-Hydroxybutyric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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