Document Detail

Does isotretinoin therapy have any effects on electrocardiography, heart rate and blood pressure?
MedLine Citation:
PMID:  21254889     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Isotretinoin therapy is associated with numerous adverse effects of various systems. Although some cases have been reported, cardiac side effects are rare following isotretinoin treatment.
OBJECTIVE: To investigate the effects of isotretinoin on the cardiovascular system.
METHODS: Seventy patients with acne vulgaris were enrolled in the study. The patients were treated with a dose of 0.5-1.0 mg/kg per day of isotretinoin. Screening for biochemical and hematologic parameters, heart rate, blood pressure and electrocardiographic parameters were done before treatment and after 3 months of isotretinoin treatment.
RESULTS: Heart rate, systolic/diastolic tension and electrocardiographic parameters (P-wave duration and QTc duration) were not statistically different before compared with after treatment.
CONCLUSION: As far as we know, there is no study researching the effect of isotretinoin on P- and QT-wave measurements in the literature. We found that isotretinoin did not affect P- and QT-wave measurement. Further studies with longer periods of follow-up are needed to understand the effect of isotretinoin on the cardiovascular system.
Ayse Serap Karadag; Hasan Ali Gumrukcuoglu; Serap Gunes Bilgili; Hatice Uce Ozkol; Derun Taner Ertugrul; Hakki Simsek; Musa Sahin; Omer Calka
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Publication Detail:
Type:  Journal Article     Date:  2011-01-22
Journal Detail:
Title:  The Journal of dermatological treatment     Volume:  23     ISSN:  1471-1753     ISO Abbreviation:  J Dermatolog Treat     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-15     Completed Date:  2012-09-27     Revised Date:  2014-07-16    
Medline Journal Info:
Nlm Unique ID:  8918133     Medline TA:  J Dermatolog Treat     Country:  England    
Other Details:
Languages:  eng     Pagination:  168-71     Citation Subset:  IM    
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MeSH Terms
Acne Vulgaris / drug therapy*
Blood Pressure / drug effects*
Blood Pressure Determination / methods
Cardiovascular System / drug effects
Dermatologic Agents / adverse effects,  therapeutic use*
Electrocardiography / drug effects*
Heart Rate / drug effects*
Isotretinoin / adverse effects,  therapeutic use*
Young Adult
Reg. No./Substance:
0/Dermatologic Agents; EH28UP18IF/Isotretinoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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