| Does intravenous fat spare nitrogen in the injured rat? | |
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MedLine Citation:
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PMID: 6775547 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of glucose versus fat as a source of energy in parenteral nutrition is controversial, particularly when administered after trauma, injury or in sepsis. In the present series of experiments, rats undergoing laparotomy and jugular vein cannulation were infused with hypertonic glucose or Intralipid with and without amino acids. The results demonstrate that the combination of amino acids and glucose has a better nitrogen-conserving ability than amino acids and fat, lasting at least 4 days after injury. However, when infused without amino acids, fat had the same nitrogen-conserving quality as glucose. The authors attribute the improved nitrogen-conserving quality of amino acids and glucose to the specific carbohydrate influence on amino acid metabolism, an action which is specific in both protein-free and protein-containing meals but has only very limited effect in the absence of simultaneously infused or fed amino acids. In the moderately to severely injured rat, a glucose calorie is significantly more effective in sparing nitrogen than a fat calorie. |
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Authors:
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H Freund; N Yoshimura; J E Fischer |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: American journal of surgery Volume: 140 ISSN: 0002-9610 ISO Abbreviation: Am. J. Surg. Publication Date: 1980 Sep |
Date Detail:
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Created Date: 1980-12-18 Completed Date: 1980-12-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370473 Medline TA: Am J Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 377-83 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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blood,
metabolism Animals Body Weight Energy Metabolism* Fat Emulsions, Intravenous / administration & dosage, metabolism* Glucose / metabolism Liver / metabolism Muscles / metabolism Nitrogen / metabolism* Parenteral Nutrition, Total Postoperative Period Rats |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Fat Emulsions, Intravenous; 50-99-7/Glucose; 7727-37-9/Nitrogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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