Document Detail


Does interleukin-18 play a role in the pathogenesis of hepatic encephalopathy?
MedLine Citation:
PMID:  21661419     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND/AIMS: It has been suggested that the presence of inflammation may accentuate the neuropsychologic alterations in hepatic encephalopathy (HE). The aim of the study was to investigate any association between alterations in plasma levels of the pro-inflammatory cytokine IL-18 and HE.
METHODOLOGY: The study population included 63 patients with cirrhosis and 20 healthy controls. Laboratory data included international normalized ratio, plasma albumin, bilirubin, urea, creatinine, hsCRP and IL-18 (pg/mL). HE was assessed using West Haven criteria and critical flicker frequency (CFF) measurement.
RESULTS: Forty-two of the 63 cirrhotic patients had HE (4, 16, 21 and 1 patients in grade 0, 1, 2, 3, respectively). hsCRP and IL-18 were significantly increased in patients with HE compared with the control group (1.6 +/- 4.8 vs 0.5 +/- 0.8, p<0.001 and 121.4 (13.6-2043.6) vs 56.3 (13.0-174.0), p=0.006, respectively). The levels of hsCRP and IL-18 were significantly higher in the all cirrhotic patients than in the control subjects (p=0.002 and p=0.008 respectively). hsCRP was significantly higher in patients with HE (2.2 +/- 6) than in patients without HE (0.7 +/- 1.2) (p=0.013). The levels of IL-18 were found higher in patients with HE than in patients without HE [121.4 (13.6-2043.6) vs 103.8 (13.0-828.0)] but the difference was not significant (p=0.215). IL-18 was higher in patients with elevated hsCRP [124.6 (13.6-2043.6)] compared with those who had normal hsCRP [75.6 (13.0-753.2)] (p=0.029).
CONCLUSION: There is an inflammatory response in the presence of cirrhosis and HE; and IL-18 may play a role in the perpetuation of chronic inflammation.
Authors:
Ibrahim Koral Onal; Meral Akdogan; Erkin Oztas; Mustafa Balci; Mevlut Kurt; Sabite Kacar; Sedef Ozdal Kuran; Nihal Karabiber; Nurgul Sasmaz
Related Documents :
22633989 - Peritoneal dialysis patients have higher prevalence of gastrointestinal symptoms than h...
22797949 - Risk of restless legs syndrome in low socioeconomic rheumatoid arthritis patients.
9342009 - Relation between lipoprotein(a) concentrations in patients with acute-phase response an...
21991089 - Marjolin's ulcers on the thigh two years after burn.
22458329 - Dental postoperative bleeding complications in patients with suspected and documented l...
22527529 - High prevalence of elevated lead levels in pediatric dialysis patients.
23551389 - Association of streptococcus bovis endocarditis and advanced colorectal neoplasia: a ca...
7397979 - The effect of lidocaine on reentry within the his-purkinje system in man.
875439 - His bundle electrograms in 51 patients requiring permanent transvenous pacemakers.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  58     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:    2011 Mar-Apr
Date Detail:
Created Date:  2011-06-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  497-502     Citation Subset:  IM    
Affiliation:
Department of Gastroenterology, Turkiye Yuksek Ihtisas Teaching and Research Hospital, Ankara, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Laparoscopic and hand-assisted liver resection: preliminary results at a mid-sized hospital.
Next Document:  Successful adult ABO incompatible living donor liver transplantation: experience with double infusio...