| Does insulin bolster antioxidant defenses via the ERK-Akt-Nrf2 pathway ? | |
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MedLine Citation:
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PMID: 22149292 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Oxidative stress plays a fundamental role in the development of diabetes, which has become a great threaten for health in the whole world. In recent years, it has been found that, in addition to the effect on metabolism, insulin plays an antioxidant role. However, the effect of insulin on the whole antioxidant enzyme system, especially in vivo, is not completely understood. We note that, in vitro and in vivo, insulin administration could sequentially and transiently increase a battery of antioxidant enzymes through the activation of the key transcription factor nuclear factor erythroid 2 p45-related factor 2 (Nrf2). The sequential activation of extracellular signal-regulated kinases (ERK)-protein kinase B (Akt) pathway may be reuqired for insulin-induced enhancement of antioxidant defense regulated by Nrf2. Our observation leads to the hypothesis that insulin regulates the redox balance and insulin bolsters antioxidant defenses via the ERK-Akt-Nrf2 pathway. |
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Authors:
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Xin Wang; Hao Wu; Hong L Chen; Rui Liu; Jiang Z Liu; Tao Zhang; Wei H Yu; Chun X Hai |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-12 |
Journal Detail:
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Title: Antioxidants & redox signaling Volume: - ISSN: 1557-7716 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888899 Medline TA: Antioxid Redox Signal Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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the Fourth Military Medical University, Toxicology, West Changle Road , 169#, Xi'an, Shaanxi, China, 710032, +86 02984774882; wangxin8309@yahoo.cn. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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