Document Detail

Does inhaled pollen enter the sinus cavities?
MedLine Citation:
PMID:  9723566     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: While there is evidence of an increased incidence of sinusitis in patients with allergic rhinitis, it is unclear whether an allergic process occurs in the sinus tissues per se. OBJECTIVE: The purpose of this study was to determine whether inhaled pollen reaches the sinus mucosa. METHODS: Tc99m labeled ragweed pollen was inhaled by five non-atopic adults. Imaging studies of the sinuses were performed with a tomographic rotating gamma camera. To determine the sensitivity of the technique, the nose and the maxillary sinuses of cadaver heads were painted with varying amounts of Tc99m and then similarly scanned. RESULTS: Scans of the cadaver heads showed clear resolution between the nasal cavity and the maxillary sinus. It was determined that 20 microci was the smallest amount of Tc99m that could be resolved to be in the sinuses. Scans of subjects showed intense activity in the nasal cavity but none in the paranasal sinuses despite the delivery of a supraphysiologic dose of Tc99m ragweed pollen. CONCLUSION: Inhaled ragweed pollen does not appear to enter the paranasal sinuses. It is unlikely that an inhaled antigen-IgE antibody reaction occurs in the sinus mucosa.
T N Adkins; H M Goodgold; L Hendershott; R G Slavin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology     Volume:  81     ISSN:  1081-1206     ISO Abbreviation:  Ann. Allergy Asthma Immunol.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-09-16     Completed Date:  1998-09-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9503580     Medline TA:  Ann Allergy Asthma Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  181-4     Citation Subset:  IM    
Department of Internal Medicine, Saint Louis University Health Sciences Center, Missouri, USA.
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MeSH Terms
Maxillary Sinus / radionuclide imaging
Maxillary Sinusitis / radionuclide imaging*
Nasal Cavity / radionuclide imaging
Nasal Mucosa / radionuclide imaging
Technetium / diagnostic use
Reg. No./Substance:

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