| Does increasing the steroid dose enhance the efficacy of the antiemetic combination of granisetron and methylprednisolone in gynecologic cancer patients--a randomized study. | |
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MedLine Citation:
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PMID: 15036719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The authors administered two doses of oral methylprednisolone in combination with 3mg granisetron intravenously for the prophylaxis of cisplatin-induced emesis in gynecologic cancer patients. MATERIALS AND METHODS: Thirty-nine patients received 100mg (group A) and 25 received 200mg (group B) methylprednisolone in the antiemetic combination in a randomized prospective trial. RESULTS: No vomiting in 90.2 and 96.7%, one emetic episode in 3 and 1.1% and two episodes in 3 and 2.2% were detected in groups A and B, respectively. More than two emetic episodes were considered to be a failure and were observed only in group A (3.8%). There was no significant difference between the two treatment groups (P=0.3160). CONCLUSIONS: There was no evidence for enhanced antiemetic effect of elevated steroidal dose in combination with granisetron. |
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Authors:
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Ottó Lehoczky; János Udvary; Andrea Bagaméri; Tamás Pulay |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 113 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-03-23 Completed Date: 2004-06-17 Revised Date: 2006-04-24 |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
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Languages: eng Pagination: 94-7 Citation Subset: IM |
Affiliation:
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Gynecologic Oncology Department, National Institute of Oncology, Rath Gy.u. 7-9, H-1122 Budapest, Hungary. lehoczky@oncol.hu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antiemetics / administration & dosage* Antineoplastic Combined Chemotherapy Protocols / adverse effects Drug Administration Schedule Endometrial Neoplasms / drug therapy Female Granisetron / administration & dosage* Humans Methylprednisolone / administration & dosage* Middle Aged Ovarian Neoplasms / drug therapy Prospective Studies Treatment Outcome Vomiting / chemically induced, drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Antiemetics; 109889-09-0/Granisetron; 83-43-2/Methylprednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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