Document Detail

Does increasing the steroid dose enhance the efficacy of the antiemetic combination of granisetron and methylprednisolone in gynecologic cancer patients--a randomized study.
MedLine Citation:
PMID:  15036719     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The authors administered two doses of oral methylprednisolone in combination with 3mg granisetron intravenously for the prophylaxis of cisplatin-induced emesis in gynecologic cancer patients. MATERIALS AND METHODS: Thirty-nine patients received 100mg (group A) and 25 received 200mg (group B) methylprednisolone in the antiemetic combination in a randomized prospective trial. RESULTS: No vomiting in 90.2 and 96.7%, one emetic episode in 3 and 1.1% and two episodes in 3 and 2.2% were detected in groups A and B, respectively. More than two emetic episodes were considered to be a failure and were observed only in group A (3.8%). There was no significant difference between the two treatment groups (P=0.3160). CONCLUSIONS: There was no evidence for enhanced antiemetic effect of elevated steroidal dose in combination with granisetron.
Ottó Lehoczky; János Udvary; Andrea Bagaméri; Tamás Pulay
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  113     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-23     Completed Date:  2004-06-17     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  94-7     Citation Subset:  IM    
Gynecologic Oncology Department, National Institute of Oncology, Rath Gy.u. 7-9, H-1122 Budapest, Hungary.
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MeSH Terms
Antiemetics / administration & dosage*
Antineoplastic Combined Chemotherapy Protocols / adverse effects
Drug Administration Schedule
Endometrial Neoplasms / drug therapy
Granisetron / administration & dosage*
Methylprednisolone / administration & dosage*
Middle Aged
Ovarian Neoplasms / drug therapy
Prospective Studies
Treatment Outcome
Vomiting / chemically induced,  drug therapy*
Reg. No./Substance:
0/Antiemetics; 109889-09-0/Granisetron; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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