Document Detail


Does increased gamma activity in patients suffering from Parkinson' disease counteract the movement inhibiting beta activity?
MedLine Citation:
PMID:  23391866     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Akinesia and rigidity are cardinal symptoms of Parkinson's disease. Previous studies analyzing event-related desynchronisation during movement onset associated both symptoms with pathologically increased oscillations in the beta frequency range. By focusing on the movement onset only, these studies cannot, however, shed light onto the question how oscillatory activity is changed during continuous movements. To investigate this issue, we compared the power of the local field potentials within and above the subthalamic nucleus (STN) during rest, an isometric hold condition of the forearm, and a fist flexion and extension task in 13 patients with idiopathic Parkinson's disease during implantation of deep brain stimulation electrodes. During fist flexion and extension (relative to rest), significantly increased activity in the low beta (12-18 Hz) and gamma (30-48 Hz) frequency ranges was observed within the STN, while during hold (compared to rest) no significant difference was found. For the regions above the STN the power during fist movements (compared to rest) was significantly higher, i.e., in the range from 18-30 Hz, with no significant changes in the gamma frequency range. Beta activity is claimed to inhibit movement and thereby could render fist movements more exhausting. Therefore, the observed increase in beta activity in the STN during fist movements might result in bradykinesia as experienced by many patients. We hypothesize that in order to enable repetitive fist movement despite increased beta activity, "prokinetic" gamma activity may be increased as a compensatory mechanism.
Authors:
Esther Florin; Richard Erasmi; Christiane Reck; Mohammad Maarouf; Alfons Schnitzler; Gereon R Fink; Lars Timmermann
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-4
Journal Detail:
Title:  Neuroscience     Volume:  -     ISSN:  1873-7544     ISO Abbreviation:  Neuroscience     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013. Published by Elsevier Ltd.
Affiliation:
Department of Neurology, University Hospital Cologne, Kerpener Str. 62, 50937 Köln, Germany; Institute of Neuroscience and Medicine (INM-3), Cognitive Neurology Section, Research Center Jülich, Leo-Brandt-Str. 5, 52425 Jülich, Germany; McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Canada. Electronic address: lars.timmermann@uk-koeln.de.
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