| Does incorporation of aids and devices make a difference in the score of the health assessment questionnaire-disability index? Analysis from a scleroderma clinical trial. | |
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MedLine Citation:
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PMID: 18085737 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The Health Assessment Questionnaire-Disability Index (HAQ-DI) is a commonly used musculoskeletal-targeted measure in systemic sclerosis (SSc). We assessed if HAQ-DI scores are different when calculated with and without aids/devices, and if apparent responsiveness changes when scored in these 2 ways. METHODS: We used data from a placebo-controlled clinical trial in diffuse SSc. Baseline HAQ-DI total score was calculated with and without aids/devices and compared using Student's t-test. We also classified the HAQ-DI scores into no-to-mild disability (0.00-1.00), moderate disability (1.01-2.00), and severe disability (2.01-3.00). Responsiveness to change was evaluated using the effect size (ES). RESULTS: The mean (SD) baseline HAQ-DI score was 1.33 (0.68) with aids/devices compared to HAQ-DI score 1.16 (0.70) without aids/devices (p = 0.03). When the baseline HAQ-DI score was categorized into no-to-mild, moderate, and severe disability, the proportion of patients in the no-to-mild disability (29% with aids/devices vs 44% without aids/devices) and moderate disability (59% with aids/devices vs 45% without aids/devices) groups were statistically different (p <0.001). The ES was similar between the 2 groups (ES = 0.01 and 0.02 with and without aids/devices). CONCLUSION: This analysis suggests a shift from no-to-mild disability to moderate disability when aids/devices are incorporated in total HAQ-DI score. Future clinical trials in SSc should explicitly state whether HAQ-DI score was calculated using aids/devices. |
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Authors:
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Dinesh Khanna; Philip J Clements; Arnold E Postlethwaite; Daniel E Furst |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2007-12-15 |
Journal Detail:
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Title: The Journal of rheumatology Volume: 35 ISSN: 0315-162X ISO Abbreviation: J. Rheumatol. Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-03-06 Completed Date: 2008-06-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: Canada |
Other Details:
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Languages: eng Pagination: 466-8 Citation Subset: IM |
Affiliation:
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Division of Rheumatology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA. dkhanna@mednet.ucla.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Activities of Daily Living Clinical Trials as Topic Cohort Studies Disability Evaluation* Humans Questionnaires* Reproducibility of Results Scleroderma, Diffuse* Self-Help Devices* Severity of Illness Index* |
| Grant Support | |
ID/Acronym/Agency:
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K23 AR053858-01A1/AR/NIAMS NIH HHS; N01AR092242/AR/NIAMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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