Document Detail

Does immunosuppressant medication lower blood pressure and arterial stiffness in patients with chronic kidney disease? An observational study.
MedLine Citation:
PMID:  20962786     Owner:  NLM     Status:  In-Process    
Chronic kidney disease is a proinflammatory state associated with increased arterial stiffness. We hypothesized that chronic kidney disease patients on long-term immunosuppression would have lower arterial stiffness and require treatment with less antihypertensive medication compared with non-immunosuppressed patients. A total of 254 patients (97 on immunosuppression) with chronic kidney disease were recruited from specialist renal clinics. Brachial blood pressure, central aortic pressure and waveform and pulse wave velocity were measured. Age, peripheral blood pressure and pulse wave velocity increased with worsening renal function but were not different between immunosuppressed and non-immunosuppressed patients. Central systolic (P < 0.001) and pulse pressure (P = 0.003) and the number of antihypertensive medications (P < 0.001) increased with worsening renal function and were higher in non-immunosuppressed patients (P = 0.02, P = 0.004 and P < 0.001, respectively). Age, mean arterial pressure, number of antihypertensive medications and a diagnosis of diabetes were found to be independent predictors of pulse wave velocity (R(2) = 0.375; P < 0.001). In a subgroup of 30 patient pairs without diabetes mellitus and cardiovascular disease and with a proven renal diagnosis, carefully matched for age, gender, renal function and systolic pressure, the prescribed antihypertensive medication remained lower in the immunosuppressed patients compared with non-immunosuppressed patients (P = 0.04). Pulse wave velocity was lower in the immunosuppressed group (7.5 ± 1.8 vs. 8.8 ± 1.9 m s(-1); P = 0.02). This study suggests that immunosuppression might be a method of reducing blood pressure and arterial stiffness in patients with chronic kidney disease.
Charles J Ferro; Nicola C Edwards; Colin Hutchison; Paul Cockwell; Rick P Steeds; Caroline O Savage; Jonathan N Townend; Lorraine Harper
Related Documents :
20408256 - Environmental determinants of blood pressure, arterial stiffness, and central hemodynam...
12074356 - The relationship between body mass index and pulse pressure in older adults with isolat...
986616 - Intraluminal pressure of the small intestine of the unanesthetized dog.
2248826 - Comparison of pulse oximeters: accuracy at low arterial pressure in volunteers.
15163256 - Clozapine and hypertension: a chart review of 82 patients.
2691056 - Epidemiology of high blood pressure.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-21
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  34     ISSN:  1348-4214     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  113-9     Citation Subset:  IM    
Department of Nephrology, University of Birmingham and University Hospital Birmingham, Birmingham, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Grant Support
//British Heart Foundation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Does primary aldosteronism exist in normotensive and mildly hypertensive patients, and should we loo...
Next Document:  Relationship between chronic kidney disease and sleep blood pressure in patients with sleep apnea sy...