| Does hypothermic fibrillatory arrest improve myocardial protection during emergency revascularization? | |
| | |
MedLine Citation:
|
PMID: 2764598 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Hypothermic fibrillatory arrest (HFA) was compared with conventional hypothermic cardioplegic arrest (HCA) in a model of acute regional ischemia. In 20 pigs, the left anterior descending coronary artery was occluded for 30 minutes before cardiopulmonary bypass. In the HCA group (n = 10), the heart was arrested with a hyperkalemic cold crystalloid solution, whereas in HFA animals (n = 10), the heart was vented and allowed to fibrillate spontaneously without cross-clamping. Miniature pH probes monitored intramyocardial pH during 45 minutes of arrest (HCA or HFA, both with systemic and topical myocardial cooling) and during two hours of coronary reperfusion. Hypothermic fibrillatory arrest did not ameliorate the acidosis in the ischemic (left anterior descending) region; indeed, after two hours of coronary reperfusion, there was a trend toward more acidosis in the postischemic left anterior descending territory in the HFA group. However, HFA did prevent acidosis in the nonischemic (left circumflex) territory. Infarct size expressed as percent of region at risk was 18.1% +/- 3.2% (mean +/- standard error of the mean) in the HCA animals and 18.8% +/- 4.4% in the HFA animals. These results demonstrate that HFA offers no advantage over HCA in protection of regionally ischemic myocardium in a model with minimal collateral circulation. |
| | |
Authors:
|
P S Greene; D E Cameron; E M Griffiths; J M DiNatale; T J Gardner |
Related Documents
:
|
2453038 - Sudden death associated with alcohol consumption. 12386498 - Alternative ventilation strategies in cardiopulmonary resuscitation. 16148478 - Oxidant injury occurs rapidly after cardiac arrest, cardiopulmonary resuscitation, and ... 11427098 - Cardiac arrest in medical and dental practices: implications for automated external def... 15824078 - A dynamic model forecasting myocardial infarct size before, during, and after reperfusi... 16898848 - A multi-country health economic evaluation of highly concentrated n-3 polyunsaturated f... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The Annals of thoracic surgery Volume: 48 ISSN: 0003-4975 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 1989 Jul |
Date Detail:
|
Created Date: 1989-09-18 Completed Date: 1989-09-18 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 38-42 Citation Subset: AIM; IM |
Affiliation:
|
Division of Cardiac Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cardiopulmonary Bypass Emergencies Female Heart Arrest, Induced / methods* Hydrogen-Ion Concentration Male Myocardial Reperfusion Injury / prevention & control* Myocardial Revascularization* Swine Ventricular Fibrillation* |
| Grant Support | |
ID/Acronym/Agency:
|
R01 19414//PHS HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Determinants of perioperative morbidity and mortality after pneumonectomy.
Next Document: Incidence of Cell-Saver contamination during cardiopulmonary bypass.