| Does hypothermia or hyperkalemia influence the preconditioning response? | |
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MedLine Citation:
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PMID: 10225309 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ischemic preconditioning (IPC) is a potent mode of myocardial protection, but not in all models of cold cardioplegia. The present study investigates possible effects of hypothermia and hyperkalemia on the preconditioning response. Langendorff-perfused rat hearts were preconditioned (2 min global ischemia and 5 min reperfusion) or control-perfused prior to 35 min normothermic, global ischemia (series 1, n = 17 in each group); 50 min normothermic cardioplegia (St. Thomas's II) (series 2, n = 10 in each); 75 min 23 degrees C, global ischemia (series 3, n = 7 in each); or 5 h 6-8 degrees C, global ischemia (series 4, n = 9 in each). Left ventricular developed (LVDP) and end-diastolic (LVEDP) pressures, coronary flow (CF), heart rate, incidence of severe reperfusion arrhythmias, and release of troponin T (TnT) were measured. IPC attenuated reduction of LVDP and CF, and increase of LVEDP during reperfusion in series 1-3. TnT release was reduced by IPC in series 3 only. IPC did not attenuate dysfunction after hypothermic ischemia (series 4). Neither hyperkalemia nor moderate hypothermia alone inhibited the preconditioning response, but IPC was not protective in deep hypothermia. |
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Authors:
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S Takeshima; J Vaage; C Löwbeer; G Valen |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian cardiovascular journal : SCJ Volume: 33 ISSN: 1401-7431 ISO Abbreviation: Scand. Cardiovasc. J. Publication Date: 1999 |
Date Detail:
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Created Date: 1999-06-09 Completed Date: 1999-06-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9708377 Medline TA: Scand Cardiovasc J Country: NORWAY |
Other Details:
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Languages: eng Pagination: 79-87 Citation Subset: IM |
Affiliation:
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Department of Thoracic Surgery, Karolinska Hospital, Stockholm, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Circulation Heart / physiology* Heart Arrest, Induced* Hyperkalemia / physiopathology* Ischemic Preconditioning, Myocardial* Rats Rats, Sprague-Dawley Troponin T / secretion Ventricular Function, Left Ventricular Pressure |
| Chemical | |
Reg. No./Substance:
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0/Troponin T |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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