Document Detail

Does the histaminergic system mediate bombesin/GRP-induced suppression of food intake?
MedLine Citation:
PMID:  7810769     Owner:  NLM     Status:  MEDLINE    
Bombesin (BN) and its mammalian homologue, gastrin-releasing peptide (GRP), are potent satiety agents and have been implicated in the physiological regulation of food intake. The mechanism(s) of action of this effect remains unclear. There is a functional and anatomic overlap between histamine and BN in relationship to feeding, which led us to hypothesize that BN may mediate its satiety effects through activation of the histaminergic system. To assess this contention, we examined the effects of R-alpha-methylhistamine (alpha-MH) and Imetit, selective H3-receptor agonists that inhibit the release and synthesis of histamine, on BN- or cholecystokinin (CCK)-induced satiety. In this report we present the first evidence for the role of histamine H3 receptors in the mediation of BN-elicited satiety. During the first hour of the 4-h daily feeding session, BN reduced food intake by > 50% relative to the control condition; this suppression was blocked by prior treatment with the H3-receptor agonist, alpha-MH. This blockade of BN-induced satiety was dose related and selective to BN as alpha-MH failed to attenuate sulfated CCK-8-induced satiety. When alpha-MH was administered alone, it failed to significantly affect food intake. The specificity of this effect was further supported by the demonstration that another H3 agonist, Imetit, was also able to block the feeding-suppressant effects of BN. Furthermore, thioperamide, an H3-receptor antagonist, blocked these effects of Imetit.(ABSTRACT TRUNCATED AT 250 WORDS)
Z Merali; K Banks
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  267     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-01-27     Completed Date:  1995-01-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R1589-95     Citation Subset:  IM    
School of Psychology, University of Ottawa, Ontario, Canada.
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MeSH Terms
Behavior, Animal / drug effects
Bombesin / pharmacology*
Eating / drug effects*
Gastrin-Releasing Peptide
Histamine / physiology*
Histamine Agonists / pharmacology
Histamine Antagonists
Imidazoles / pharmacology
Methylhistamines / pharmacology
Motor Activity / drug effects
Peptides / pharmacology*
Piperidines / pharmacology
Rats, Sprague-Dawley
Satiation / drug effects
Sincalide / pharmacology
Thiourea / analogs & derivatives,  pharmacology
Reg. No./Substance:
0/Histamine Agonists; 0/Histamine Antagonists; 0/Imidazoles; 0/Methylhistamines; 0/Peptides; 0/Piperidines; 102203-18-9/imetit; 106243-16-7/thioperamide; 25126-32-3/Sincalide; 31362-50-2/Bombesin; 51-45-6/Histamine; 62-56-6/Thiourea; 6986-90-9/alpha-methylhistamine; 80043-53-4/Gastrin-Releasing Peptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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