Document Detail


Does the gut microbiota have a role in type 1 diabetes? Early evidence from humans and animal models of the disease.
MedLine Citation:
PMID:  22875196     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite years of appreciating the potential role of environment to influence the pathogenesis of type 1 diabetes, specific agents or mechanisms serving in such a capacity remain ill defined. This is exceedingly disappointing as the identification of factors capable of modulating the disease, either as triggers or regulators of the autoimmune response underlying type 1 diabetes, would not only provide clues as to why the disorder develops but, in addition, afford opportunities for improved biomarkers of disease activity and the potential to design novel therapeutics capable of disease abatement. Recent improvements in sequencing technologies, combined with increasing appreciation of the role of innate and mucosal immunity in human disease, have stirred strong interest in what is commonly referred to as the 'gut microbiota'. The gut (or intestinal) microbiota is an exceedingly complex microenvironment that is intimately linked with the immune system, including the regulation of immune responses. After evaluating evidence supporting a role for environment in type 1 diabetes, this review will convey current notions for contributions of the gut microbiota to human health and disease, including information gleaned from studies of humans and animal models for this autoimmune disorder.
Authors:
M A Atkinson; A Chervonsky
Related Documents :
17875506 - Clinical and pathologic analysis of 16 cases of relapsed chronic myeloid leukemia after...
16135836 - Recombinant osteoprotegerin for juvenile paget's disease.
3941136 - Paget's disease and metastatic carcinoma. a case report.
22424236 - Personal omics profiling reveals dynamic molecular and medical phenotypes.
21139416 - Pink1-parkin-dependent mitophagy involves ubiquitination of mitofusins 1 and 2: implica...
24829596 - Idiopathic small fiber neuropathy: phenotype, etiologies, and the search for fabry dise...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-08-09
Journal Detail:
Title:  Diabetologia     Volume:  55     ISSN:  1432-0428     ISO Abbreviation:  Diabetologia     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-11     Completed Date:  2013-02-26     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  0006777     Medline TA:  Diabetologia     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  2868-77     Citation Subset:  IM    
Affiliation:
Department of Pathology, University of Florida, College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610-0275, USA. atkinson@ufl.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Diabetes Mellitus, Type 1 / immunology*,  microbiology*,  physiopathology
Disease Models, Animal
Humans
Immunity, Innate / physiology*
Intestines / immunology,  microbiology*
Metagenome / physiology*
Grant Support
ID/Acronym/Agency:
P30 DK042086/DK/NIDDK NIH HHS; R01 AI039250/AI/NIAID NIH HHS; R01 AI082418/AI/NIAID NIH HHS; UL1 TR000064/TR/NCATS NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cancer outcomes and all-cause mortality in adults allocated to metformin: systematic review and coll...
Next Document:  Considerations in determination of residual moisture in lyophilized demineralized bone matrix: the r...