| Does granisetron eliminate the gag reflex? A crossover, double-blind, placebo-controlled pilot study. | |
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MedLine Citation:
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PMID: 19562886 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although gagging is a frequent problem that, when severe, can jeopardize the dental procedure, no single protocol is used to alleviate this phenomenon. Selective 5-HT3 antagonists, such as granisetron, may attenuate gagging. In this study, granisetron and placebo were administered intravenously, in a crossover, double-blind manner, to 25 healthy volunteers in 2 different sessions. Gagging levels were recorded before and after administration, as were BP, pulse, and O2 saturation. Recorded results were analyzed with the use of tests for nonparametric values (P = .05). A significant increase in the depth of swab insertion was noted after administration of both placebo and drug. The increase in drug effectiveness correlated with decreased body weight. The true efficacy of granisetron in gagger patients with this treatment protocol has yet to be fully established, although it has been theorized that an increased dosage of granisetron may have a better effect. |
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Authors:
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Silvina Friedlander Barenboim; Vladislav Dvoyris; Eliezer Kaufman |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Anesthesia progress Volume: 56 ISSN: 0003-3006 ISO Abbreviation: Anesth Prog Publication Date: 2009 |
Date Detail:
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Created Date: 2009-06-30 Completed Date: 2009-07-14 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0043533 Medline TA: Anesth Prog Country: United States |
Other Details:
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Languages: eng Pagination: 3-8 Citation Subset: D |
Affiliation:
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Department of Oral Medicine, Hebrew University-Hadassah School of Dental Medicine, Jerusalem, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Body Weight Cross-Over Studies Double-Blind Method Female Gagging / prevention & control* Granisetron / administration & dosage, therapeutic use* Humans Injections, Intravenous Male Serotonin Antagonists / administration & dosage, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Serotonin Antagonists; 109889-09-0/Granisetron |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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