Document Detail

Does glutamine have a role in reducing infections in athletes?
MedLine Citation:
PMID:  8803512     Owner:  NLM     Status:  MEDLINE    
There is an increased risk of infections in athletes undertaking prolonged, strenuous exercise. There is also some evidence that cells of the immune system are less able to mount a defence against infections after such exercise. The level of plasma glutamine, an important fuel for cells of the immune system, is decreased in athletes after endurance exercise; this may be partly responsible for the apparent immunosuppression which occurs in these individuals. We monitored levels of infection in more than 200 runners and towers. The levels of infection were lowest in middle-distance runners, and highest in runners after a full or ultramarathon and in elite rowers after intensive training. In the present study, athletes participating in different types of exercise consumed two drinks, containing either glutamine (Group G) or placebo (Group P) immediately after and 2 h after exercise. They subsequently completed questionnaires (n = 151) about the incidence of infections during the 7 days following the exercise. The percentage of athletes reporting no infections was considerably higher in Group G (81%, n = 72) than in Group P (49%, n = 79, p < 0.001).
L M Castell; J R Poortmans; E A Newsholme
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of applied physiology and occupational physiology     Volume:  73     ISSN:  0301-5548     ISO Abbreviation:  Eur J Appl Physiol Occup Physiol     Publication Date:  1996  
Date Detail:
Created Date:  1996-12-05     Completed Date:  1996-12-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0410266     Medline TA:  Eur J Appl Physiol Occup Physiol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  488-90     Citation Subset:  IM    
University Department of Biochemistry, Oxford, UK.
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MeSH Terms
Glutamine / blood,  therapeutic use*
Immune Tolerance / physiology
Infection / etiology*
Physical Endurance / physiology
Physical Fitness / physiology*
Reg. No./Substance:

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