Document Detail

Does glucagon enhance opacification of the bile ducts during intravenous cholangiography? An experimental study in dogs.
MedLine Citation:
PMID:  7076434     Owner:  NLM     Status:  MEDLINE    
To determine the rational for the ability of glucagon to enhance opacification of the bile ducts during intravenous cholangiography, which has been claimed in recent clinical reports, experiments were performed in dogs which had had Thomas cannulas inserted. A constant step-wise infusion of iodipamide was administered with or without a bolus injection and constant infusion of glucagon. At every infusion rate of iodipamide the biliary concentration of the contrast agent was less when glucagon was administered. Glucagon caused a choleresis, but had no effect on the rate of excretion of iodipamide. It is concluded that the theory that glucagon is of value to improve opacification of the bile ducts during intravenous cholangiography is unlikely to be confirmed by further clinical trials.
R N Berk; J L Barnhart; G D Nazareno; N D Brourman; L Flamm
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Investigative radiology     Volume:  17     ISSN:  0020-9996     ISO Abbreviation:  Invest Radiol     Publication Date:    1982 Jan-Feb
Date Detail:
Created Date:  1982-07-08     Completed Date:  1982-07-08     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0045377     Medline TA:  Invest Radiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  50-2     Citation Subset:  IM    
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MeSH Terms
Bile Acids and Salts / secretion
Glucagon / diagnostic use,  pharmacology*
Iodipamide / diagnostic use
Grant Support
Reg. No./Substance:
0/Bile Acids and Salts; 606-17-7/Iodipamide; 9007-92-5/Glucagon

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