Document Detail

Does gestational age affect the pharmacokinetics and pharmacodynamics of lidocaine in mother and fetus?
MedLine Citation:
PMID:  3125767     Owner:  NLM     Status:  MEDLINE    
The pharmacokinetics and pharmacodynamics of lidocaine were studied in nine chronically prepared pregnant ewes and their fetuses at a mean ( +/- SE) gestation of 119 +/- 1.0 days, and the results were compared to the data previously published for ten animals at 138 +/- 1.2 days of gestation (term 148 days). Lidocaine was infused intravenously to the mother at a constant rate of 0.1 over a period of 180 min, in order to reach a steady-state maternal plasma lidocaine concentration of approximately 2 micrograms/ml. Maternal and fetal blood samples and maternal urine were collected at intervals throughout the infusion for determination of pH, blood gases, and lidocaine concentrations. Maternal and fetal heart rate, blood pressure, and intraamniotic pressure were continuously recorded. Fetal cardiac output and organ blood flow were determined before and at the end of lidocaine infusion using radionuclide-labeled microspheres. Lidocaine tissue concentrations were determined in several maternal and fetal organs excised at the end of infusion. In both groups, the steady-state plasma concentrations of lidocaine were similar; namely, 2.3 +/- 0.17 and 2.1 +/- 0.21 micrograms/ml in preterm and term ewes, respectively. There were also no significant differences in steady-state plasma drug concentrations in preterm and term fetuses (1.3 +/- 0.11 and 1.2 +/- 0.15 micrograms/ml). The mean fetal maternal concentration ratios (F/M) were the same; namely, 0.6. Maternal urinary excretion of lidocaine correlated with urine pH, being greater in the more acid urine. Tissue uptake of drug tended to be higher in the preterm than term mothers, but only significantly so in the brain and adrenals.(ABSTRACT TRUNCATED AT 250 WORDS)
H Pedersen; A C Santos; H O Morishima; M Finster; H Plosker; G R Arthur; B G Covino
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Anesthesiology     Volume:  68     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-03-28     Completed Date:  1988-03-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  367-72     Citation Subset:  AIM; IM    
Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032.
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MeSH Terms
Anesthesia, Obstetrical*
Anesthetics, Local*
Carbon Dioxide / blood
Gestational Age*
Hemodynamics / drug effects
Hydrogen-Ion Concentration
Lidocaine / pharmacokinetics*,  pharmacology
Maternal-Fetal Exchange
Oxygen / blood
Partial Pressure
Grant Support
Reg. No./Substance:
0/Anesthetics, Local; 124-38-9/Carbon Dioxide; 137-58-6/Lidocaine; 7782-44-7/Oxygen

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