Document Detail

Does gastroesophageal reflux cause apnea in preterm infants?
MedLine Citation:
PMID:  15711034     Owner:  NLM     Status:  MEDLINE    
Gastroesophageal reflux (GER) and apnea are both common occurrences in premature infants but their relationship is controversial. We present the evidence for and against an association between GER and apnea and discuss the merits and limitations of the various methodologies employed in characterizing such a relationship. Overall, GER and apnea do not appear temporally related in preterm infants, despite strong physiologic evidence that stimulation of laryngeal afferents elicits central apnea and laryngeal adduction. In a subpopulation of infants with neurodevelopmental compromise, there may be an increased incidence of both apnea and GER, although the direct association between GER and apnea in this population is unclear. Therefore, we believe there is no evidence to support widespread use of anti-reflux medications in the treatment of apnea in preterm infants. Further studies are needed to clarify the existence of a small subpopulation of infants who may have GER-induced apnea, to identify potential triggering mechanisms, and to document benefit from newer pharmacological approaches.
Eleanor J Molloy; Juliann M Di Fiore; Richard J Martin
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Publication Detail:
Type:  Journal Article; Review     Date:  2005-02-11
Journal Detail:
Title:  Biology of the neonate     Volume:  87     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  2005  
Date Detail:
Created Date:  2005-06-29     Completed Date:  2005-08-19     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  254-61     Citation Subset:  IM    
Copyright Information:
Copyright 2005 S. Karger AG, Basel
Division of Neonatology, Department of Pediatrics, Rainbow Babies and Children's Hospital, Cleveland, OH 44106, USA.
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MeSH Terms
Apnea / etiology*,  physiopathology
Gastroesophageal Reflux / complications*,  drug therapy,  physiopathology
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / drug therapy,  etiology*,  physiopathology
Models, Biological

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