| Does fractionation decrease the risk of breast cancer induced by low-LET radiation? | |
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MedLine Citation:
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PMID: 9952308 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Whether fractionation decreases the risk of breast cancer induced by low-LET radiation is a question of some importance. Analyses of the data for TB cohorts who were exposed to multiple fluoroscopies show an apparently similar breast cancer risk compared with those for the acutely exposed A-bomb survivors. However, the fluoroscopy cohorts were subjected to very much lower-energy photons (60-80 kVp) compared with the A-bomb survivors; the increased RBE associated with the low photon energies to which these fluoroscopy cohorts were exposed suggests that, in comparison to the risk estimates for the A-bomb survivors, the risk estimates from the X-ray fluoroscopy cohorts are increased because of the lower-energy X rays and decreased by a similar amount due to fractionation, resulting in an overall apparent equality of risk. Thus the results from the most powerful epidemiological data sets available for assessing breast cancer risks after fractionated exposure to low-LET radiation (the fluoroscopy cohorts) are quite consistent with a lower radiation risk for a fractionated exposure in comparison to an acute exposure. In general, for any cancer site, estimates of the dose-rate effectiveness factor (DDREF) generated by comparing the results for A-bomb survivors with those for the TB fluoroscopy cohorts should probably be roughly doubled from their apparent values because of the increased RBE of the fluoroscopy X rays. |
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Authors:
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D J Brenner |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Radiation research Volume: 151 ISSN: 0033-7587 ISO Abbreviation: Radiat. Res. Publication Date: 1999 Feb |
Date Detail:
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Created Date: 1999-02-19 Completed Date: 1999-02-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0401245 Medline TA: Radiat Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 225-9 Citation Subset: IM; S |
Affiliation:
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Center for Radiological Research, Columbia University, New York, New York 10032, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Breast Neoplasms
/
etiology*,
prevention & control* Female Fluoroscopy / adverse effects Humans Linear Energy Transfer Neoplasms, Radiation-Induced / etiology*, prevention & control* Nuclear Warfare Radiotherapy Dosage Relative Biological Effectiveness Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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CA24232/CA/NCI NIH HHS; CA77285/CA/NCI NIH HHS |
| Comments/Corrections | |
Comment In:
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Radiat Res. 1999 Jul;152(1):104-5
[PMID:
10428682
]
Radiat Res. 1999 Feb;151(2):123-4 [PMID: 9952295 ] Radiat Res. 1999 Nov;152(5):567 [PMID: 10577165 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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