Document Detail

Does fetal sex influence the risk of preterm delivery in dichorionic twin pregnancies after spontaneous conception?
MedLine Citation:
PMID:  20874473     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The incidence of preterm delivery has been increasing, and our aim was to estimate the influence of fetal sex on the risk of preterm delivery in dichorionic twins after spontaneous conception.
METHODS: 125 spontaneously conceived dichorionic twin gestations, with viable fetuses, born after 24 weeks and delivered spontaneously before 37 weeks, were enrolled. The impact of fetal sex, previous preterm delivery, maternal age, body-mass-index, smoking, and parity on gestational age at birth were evaluated.
RESULTS: Despite similar baseline characteristics in all three groups, women with one or two male fetuses delivered significantly more often before 34 weeks than patients with two female fetuses, 48% (23/48) and 43% (19/44) vs 21% (7/33), p = .04. Regression analyses, including fetal sex, maternal age, maternal body-mass-index, smoking, previous preterm delivery and parity, revealed that only fetal sex was significantly associated with spontaneous preterm delivery (p = .03).
CONCLUSION: Fetal sex appears to be a risk factor for preterm delivery in spontaneously conceived dichorionic twin gestations. Twin pregnancies with one or two male fetuses seem to be at higher risk for spontaneous preterm delivery than those with only females.
Katharina Klein; Christof Worda; Maria Stammler-Safar; Peter Husslein; Norbert Gleicher; Andrea Weghofer
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Publication Detail:
Type:  Journal Article; Twin Study    
Journal Detail:
Title:  Twin research and human genetics : the official journal of the International Society for Twin Studies     Volume:  13     ISSN:  1832-4274     ISO Abbreviation:  Twin Res Hum Genet     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-29     Completed Date:  2010-12-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101244624     Medline TA:  Twin Res Hum Genet     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  495-500     Citation Subset:  IM    
Department of Obstetrics and Feto-maternal Medicine, Medical University of Vienna, Vienna, Austria.
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MeSH Terms
Infant, Newborn
Infant, Premature
Premature Birth / etiology*,  genetics*
Regression Analysis
Risk Factors
Sex Characteristics
Twins, Dizygotic / genetics*
Young Adult

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