| Does the fetal genotype affect maternal physiology during pregnancy? | |
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MedLine Citation:
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PMID: 17900986 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Conventional wisdom states that associations between fetal growth and diseases in pregnancy, such as pregnancy-induced hypertension (PIH) and gestational diabetes (GDM), result from effects of the mother's genotype or environment acting on her physiology which subsequently affect the fetus. However, recent evidence from human mothers carrying macrosomic offspring with Beckwith Wiedemann syndrome and pregnant mice carrying p57(kip2)-null offspring suggest that variation in the fetal genome can modify maternal physiology to increase fetal nutrient delivery and optimise growth. These are some of the first documented examples of such effects, whereby the genome of one individual directly affects the physiology of another related individual from the same species. We propose that this mechanism is involved in the aetiology of PIH and GDM. |
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Authors:
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Clive J Petry; Ken K Ong; David B Dunger |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2007-09-27 |
Journal Detail:
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Title: Trends in molecular medicine Volume: 13 ISSN: 1471-4914 ISO Abbreviation: Trends Mol Med Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-10-19 Completed Date: 2008-01-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100966035 Medline TA: Trends Mol Med Country: England |
Other Details:
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Languages: eng Pagination: 414-21 Citation Subset: IM |
Affiliation:
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Department of Paediatrics, University of Cambridge, Cambridge, CB2 0QQ, UK. cjp1002@cam.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Beckwith-Wiedemann Syndrome / genetics, physiopathology Female Fetal Development / genetics, physiology* Genotype Humans Maternal-Fetal Exchange / genetics, physiology* Mice Models, Biological Pregnancy |
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