Document Detail

Does fermented milk possess antihypertensive effect in humans?
MedLine Citation:
PMID:  19387365     Owner:  NLM     Status:  MEDLINE    
The putative antihypertensive effect of milk after fermentation by lactic bacteria has attracted attention over the past 20 years. Research on fermented milk and hypertension has mainly focused on the content of peptides with in-vitro angiotensin converting enzyme-inhibitor effect. However, fermented milk products contain several proteins, peptides and minerals, all with possible different antihypertensive modes of actions. The burden of cardiovascular events in industrialized countries caused by hypertension is considerable. Diet modifications are one way to lower blood pressure, and fermented milk could be a feasible way. In this review, interventional human studies of the possible antihypertensive effect of fermented milk are evaluated. The results are diverging, and the antihypertensive effect is still debatable. Additionally, present knowledge of bioavailability and in-vivo actions of the peptides in fermented milk are discussed.
Lotte Usinger; Hans Ibsen; Lars T Jensen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of hypertension     Volume:  27     ISSN:  1473-5598     ISO Abbreviation:  J. Hypertens.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-20     Completed Date:  2009-08-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  1115-20     Citation Subset:  IM    
Department of Clinical Physiology and Nuclear Medicine, University Hospital Glostrup, Glostrup, Denmark.
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MeSH Terms
Antihypertensive Agents / pharmacokinetics,  therapeutic use
Biological Availability
Blood Pressure / drug effects
Clinical Trials as Topic
Cultured Milk Products / chemistry*,  metabolism
Hypertension / diet therapy*,  physiopathology
Milk Proteins / pharmacokinetics,  therapeutic use
Oligopeptides / pharmacokinetics
Opioid Peptides / pharmacology
gamma-Aminobutyric Acid / pharmacology
Reg. No./Substance:
0/Antihypertensive Agents; 0/Milk Proteins; 0/Oligopeptides; 0/Opioid Peptides; 56-12-2/gamma-Aminobutyric Acid

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