Document Detail

Does the expression of versican isoforms contribute to the pathogenesis of neurodegenerative diseases?
MedLine Citation:
PMID:  21722824     Owner:  NLM     Status:  In-Data-Review    
Classical neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's are most commonly seen in older persons. The incidence rate increases as life expectancy increases. Even though neuronal loss, neuronal death and accumulated toxic proteins are well investigated, the mechanism(s) of neurodegenerative disorders is not yet fully understood. Versican is a large extracellular matrix proteoglycan. Its isoforms are aberrantly expressed in central nervous system injuries. Diverse lines of evidence suggest that versican isoforms play a vital role in regulating neuronal differentiation, maturation, neurite outgrowth, and synaptic transmission. Some toxic proteins may be increased and less sensitive to degeneration due to the chondroitin sulfate (CS) chains of versicans. We propose that the patterns of versican V1 and V2 isoforms act as a fine-tuned mechanism for guiding the change of neural microenvironment, and the unbalanced expression of V1 and V2 isoforms may contribute to the pathogenesis of neurodegenerative diseases. The emergence of versican isoforms indicates that it may explain the pathogenesis of the common sporadic forms of complex diseases.
Zhen-Wei Zhang; Jian-Peng Zhang; Ting-Ting Zhou; Wei-Hua Feng; Bing-Hua Jiao
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of medical research     Volume:  42     ISSN:  1873-5487     ISO Abbreviation:  Arch. Med. Res.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-07-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9312706     Medline TA:  Arch Med Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  258-60     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 IMSS. Published by Elsevier Inc. All rights reserved.
Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, P.R. China.
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