Document Detail


Does exposure to maternal smoking during pregnancy affect the clinical features of ADHD? Results from a controlled study.
MedLine Citation:
PMID:  21545244     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Exposure to maternal smoking during pregnancy may be a significant risk factor for attention-deficit/hyperactivity disorder (ADHD) independently of family history of ADHD. The main aim of this study was to examine whether the clinical profile of ADHD differs between children with and without exposure to maternal smoking during pregnancy.
METHODS: This was a case-control study of boys and girls with and without ADHD ascertained from psychiatric and paediatric sources. Maternal smoking during pregnancy was defined by interviews with subjects' mothers. Main outcome measures were ADHD symptoms and associated clinical features in children with and without exposure to maternal smoking during pregnancy.
RESULTS: No significant differences were found between ADHD children with and without exposure to maternal smoking during pregnancy on clinical characteristics. When these analyses were repeated in the subgroup of subjects without parental history of ADHD, there were also no statistically significant differences found.
CONCLUSIONS: Despite adequate statistical power, no significant differences were found between ADHD children with and without exposure in the clinical features of ADHD and associated disorders. Results provide support for the notion that ADHD cases resulting from exposure to maternal smoking during pregnancy have similar clinical profiles as other ADHD cases.
Authors:
Joseph Biederman; Carter R Petty; Pradeep G Bhide; K Yvonne Woodworth; Stephen Faraone
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Publication Detail:
Type:  Journal Article     Date:  2011-05-05
Journal Detail:
Title:  The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry     Volume:  13     ISSN:  1814-1412     ISO Abbreviation:  World J. Biol. Psychiatry     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-19     Completed Date:  2012-04-25     Revised Date:  2013-08-19    
Medline Journal Info:
Nlm Unique ID:  101120023     Medline TA:  World J Biol Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  60-4     Citation Subset:  IM    
Affiliation:
Clinical and Research Program in Pediatric Psychiatry, Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, USA. jbiederman@partners.org
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Attention Deficit Disorder with Hyperactivity / etiology*
Child
Female
Humans
Male
Nicotine / adverse effects*
Pregnancy
Prenatal Exposure Delayed Effects*
Risk Factors
Tobacco Smoke Pollution / adverse effects*
Grant Support
ID/Acronym/Agency:
R01 DA020796/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Tobacco Smoke Pollution; 54-11-5/Nicotine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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