Document Detail


Does exposure to UV radiation induce a shift to a Th-2-like immune reaction?
MedLine Citation:
PMID:  8760564     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In addition to being the primary cause of skin cancer, UV radiation is immune suppressive and there appears to be a link between the ability of UV to suppress the immune response and induce skin cancer. Cytokines made by UV-irradiated keratinocytes play an essential role in activating immune suppression. In particular, we have found that keratinocyte-derived interleukin (IL)-10 is responsible for the systemic impairment of antigen-presenting cell function and the UV-induced suppression of delayed-type hypersensitivity (DTH). Antigen presentation by splenic adherent cells isolated from UV-irradiated mice to T helper-1 type T (Th1) cells is suppressed, whereas antigen presentation to T helper-2 type T (Th2) cells is enhanced. The enhanced antigen presentation to Th2 cells and the impaired presentation to Th1 cells can be reversed in vivo by injecting the UV-irradiated mice with monoclonal anti-IL-10 antibody. Furthermore, immune suppression can be transferred from UV-irradiated mice to normal recipients by adoptive transfer of T cells. Injecting the recipient mice with anti-IL-4 or anti-IL-10 prevents the transfer of immune suppression, suggesting the suppressor cells are Th2 cells. In addition, injecting UV-irradiated mice with IL-12, a cytokine that has been shown to be the primary inducer of Th1 cells, and one that prevents the differentiation of Th2 cells in vivo, reverses UV-induced immune suppression. These findings support the hypothesis that UV exposure activates IL-10 secretion, which depresses the function of Th1 cells, while enhancing the activity of Th2 cells.
Authors:
S E Ullrich
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Photochemistry and photobiology     Volume:  64     ISSN:  0031-8655     ISO Abbreviation:  Photochem. Photobiol.     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1996-10-01     Completed Date:  1996-10-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376425     Medline TA:  Photochem Photobiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  254-8     Citation Subset:  IM; X    
Affiliation:
Department of Immunology, University of Texas, M.D. Anderson Cancer Center, Houston 77030-4095, USA. sullrich@notes.mdacc.tmc.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Th1 Cells / immunology,  radiation effects
Th2 Cells / immunology*,  radiation effects*
Ultraviolet Rays / adverse effects*
Grant Support
ID/Acronym/Agency:
AR 40824/AR/NIAMS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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