Document Detail


Does the expired-air carbon monoxide level reflect the severity of inflammation in COPD?
MedLine Citation:
PMID:  17972536     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The aim of this study is to evaluate the expired-air carbon monoxide level which relates to the severity of inflammation in patients with chronic obstructive pulmonary disease (COPD). DESIGN: Cross sectional study. SETTING: Cukurova University, Faculty of Medicine, Department of Chest Disease, Out-patient clinic. PATIENTS: The characteristics of patients enrolled in this study were following; 20 ex-smokers with stable COPD (mean age: 68.8 +/- 7.2 years, FEV1: 45.6 +/- 16.6% of predicted), 22 current smokers with stable COPD (mean age: 58.7 +/- 8.2 years, FEVI: 57.5 +/- 20.9% of predicted), 20 healthy smokers (mean age: 55.916.0 years, FEVI: 86.7 +/- 14.2% of predicted), and 20 healthy non-smokers (mean age: 60.8 +/- 9.2 years, FEV1: 95.3 +/- 13.5% of predicted). INTERVENTION: CO level was measured in expired-air. MEAAUREMENT AND RESULTS: The measurement of expired-air CO level was measured by DisCOver, carbon monoxide analyser. It is known that the level of expired-air carbon monoxide in healthy smokers (11.8 +/- 6.4 ppm) and in current smokers with COPD (11.1 +/- 7.4 ppm) is higher than in healthy non-smokers (1.7:0.7 ppm) and in ex-smokers with COPD (2.0 +/- 1.8 ppm) (p = 0.0001). CONCLUSION: We assumed that the level of expired-air carbon monoxide may not useful in assessing the severity of inflammation in COPD (Tab. 1, Fig. 2, Ref. 23).
Authors:
I Hanta; A Kocabas; O Olgunus; S Satar; G Seydaoglu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bratislavské lekárske listy     Volume:  108     ISSN:  0006-9248     ISO Abbreviation:  Bratisl Lek Listy     Publication Date:  2007  
Date Detail:
Created Date:  2007-11-01     Completed Date:  2008-01-10     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0065324     Medline TA:  Bratisl Lek Listy     Country:  Slovakia    
Other Details:
Languages:  eng     Pagination:  255-8     Citation Subset:  IM    
Affiliation:
Department of Chest Diseases, Cukurova University, School of Medicine, Balcali-Adana, Turkey. ihanta@cu.edu.tr
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MeSH Terms
Descriptor/Qualifier:
Aged
Breath Tests*
Carbon Monoxide / analysis*
Female
Forced Expiratory Volume
Humans
Inflammation
Male
Middle Aged
Pulmonary Disease, Chronic Obstructive / metabolism,  pathology*,  physiopathology
Chemical
Reg. No./Substance:
630-08-0/Carbon Monoxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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