Document Detail


Does exercise training prior to ovariectomy protect against liver and adipocyte fat accumulation in rats?
MedLine Citation:
PMID:  19657790     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether a training state protects against the metabolically deleterious effects of ovariectomy on liver and adipocyte fat accumulation in rats. DESIGN: Female rats were randomly assigned to each group (n = 8 rats/group). The animals were first either exercise-trained (Tr) for 6 weeks or kept sedentary (Sed) before being sham-operated (Sham), ovariectomized (Ovx), or ovariectomized with 17beta-estradiol supplementation (OvxE2). Following surgery, sedentary rats either remained sedentary (Sed-Sed) or undertook exercise training for 6 weeks (Sed-Tr) while exercise-trained rats either became sedentary (Tr-Sed) or resumed exercise training (Tr-Tr). RESULTS: Body weight and energy intake along with intra-abdominal and subcutaneous fat pad weights and homeostasis model assessment of insulin resistance (HOMA-IR) were significantly (p < 0.01) increased in the Ovx group compared to the Sham and OvxE2 groups. Rats kept in a sedentary state after surgery showed the higher (p < 0.05) values for all of these variables whether they were trained or not before surgery (Sed-Sed and Tr-Sed), indicating no protective effect of a previous exercise-trained state. On the other hand, training conducted after surgery resulted in a lowering of fat mass and HOMA-IR whether rats had been trained or not before surgery (Sed-Tr and Tr-Tr), indicating the effectiveness of exercise training even initiated after surgery. These responses were independent of surgery. Interestingly, liver triacylglycerol concentrations followed a pattern of responses identical to fat mass with the exception that all of the responses were observed only in the Ovx group (p < 0.05). CONCLUSION: There is no protective effect of a previous exercise-training state on ovariectomy-induced liver and adipocyte fat accumulation if rats remain sedentary after ovariectomy. However, training conducted concurrently with estrogen withdrawal has protective effects, especially on liver fat accumulation, whether or not rats were previously trained.
Authors:
A Pighon; R Barsalani; S Yasari; D Prud'homme; J-M Lavoie
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Climacteric : the journal of the International Menopause Society     Volume:  13     ISSN:  1473-0804     ISO Abbreviation:  Climacteric     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-04-28     Completed Date:  2010-08-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9810959     Medline TA:  Climacteric     Country:  England    
Other Details:
Languages:  eng     Pagination:  238-48     Citation Subset:  IM    
Affiliation:
Department of Kinesiology, University of Montreal, Montreal, Canada.
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MeSH Terms
Descriptor/Qualifier:
Abdominal Fat / pathology*
Animals
Blood Glucose / analysis
Estradiol / pharmacology
Estrogens / pharmacology
Fatty Acids, Nonesterified / blood
Fatty Liver / pathology,  prevention & control*
Female
Liver / metabolism
Muscle, Skeletal / anatomy & histology
Organ Size
Ovariectomy*
Physical Conditioning, Animal*
Preoperative Care*
Random Allocation
Rats
Rats, Sprague-Dawley
Triglycerides / metabolism
Uterus / anatomy & histology
Grant Support
ID/Acronym/Agency:
T 0602 145.02//Canadian Institutes of Health Research
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Estrogens; 0/Fatty Acids, Nonesterified; 0/Triglycerides; 50-28-2/Estradiol

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