Document Detail

Does exercise-induced severe ischaemia result in elevation of plasma troponin-T level in patients with chronic coronary artery disease?
MedLine Citation:
PMID:  11918128     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: It has been reported that the loss of cell membrane integrity during severe reversible ischaemia results in elevation of plasma troponin T (TnT) in unstable angina. We investigated whether TnT is released into circulation during severe ischaemia (e.g. on treadmill exercise testing) in patients with chronic coronary artery disease (CAD). METHODS AND RESULTS: The study comprised 54 patients who had angiographically documented CAD (22 of them had a prior history of myocardial infarction) and 18 normal subjects. All cases underwent exercise thallium (Tl)-201 SPECT myocardial perfusion imaging. Blood samples for TnT analysis were obtained for each patient at pre-exercise, immediately after and 12 hours after exercise. SPECT images were divided into 20 segments. Patients with redistribution defects > or = 5 were considered to have severe ischaemia. Sixteen patients had severe ischaemia on SPECT images. The mean TnT levels of the patients with severe ischaemia at pre-exercise, immediately after and 12 hours after exercise were 0.009 +/- 0.008, 0.012 +/- 0.009 and 0.010 +/- 0.010 ng/ml, respectively. In normal subjects the mean TnT levels were 0.012 +/- 0.009, 0.010 +/- 0.009, 0.010 +/- 0.010 ng/ml, respectively. There was no significant difference neither between the two groups nor within each group with respect to pre-exercise and post-exercise TnT results. All TnT levels were within normal limits (< 0.1 ng/dl). Additionally, when the patients were grouped according to other SPECT variables (patients with reversible defects vs. fixed defects; patients with increased lung uptake of Tl-201 vs. without lung uptake; patients with transient left ventricle dilatation vs. those without) and angiographic findings (patients with multivessel disease vs. normal subjects), there were no significant differences with respect to pre-exercise and post-exercise TnT results. CONCLUSION: Severe ischaemia does not result in the elevation of the plasma TnT level in patients with chronic CAD.
Ilyas Akdemir; Nur Aksoy; Mehmet Aksoy; Vedat Davutoglu; Hakan Dinckal
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta cardiologica     Volume:  57     ISSN:  0001-5385     ISO Abbreviation:  Acta Cardiol     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-03-28     Completed Date:  2002-09-18     Revised Date:  2009-06-11    
Medline Journal Info:
Nlm Unique ID:  0370570     Medline TA:  Acta Cardiol     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  13-8     Citation Subset:  IM    
Department of Cardiology, Faculty of Medicine. University of Gaziantep, Turkey.
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MeSH Terms
Chronic Disease
Coronary Disease / blood*
Exercise Test*
Middle Aged
Myocardial Ischemia / blood*,  radionuclide imaging
Prospective Studies
Thallium Radioisotopes / diagnostic use
Tomography, Emission-Computed, Single-Photon
Troponin T / blood*
Reg. No./Substance:
0/Thallium Radioisotopes; 0/Troponin T

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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