| Does exercise-induced hypoxemia modify lactate influx into erythrocytes and hemorheological parameters in athletes? | |
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MedLine Citation:
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PMID: 15121747 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study investigated 1) red blood cells (RBC) rigidity and 2) lactate influxes into RBCs in endurance-trained athletes with and without exercise-induced hypoxemia (EIH). Nine EIH and six non-EIH subjects performed a submaximal steady-state exercise on a cyclo-ergometer at 60% of maximal aerobic power for 10 min, followed by 15 min at 85% of maximal aerobic power. At rest and at the end of exercise, arterialized blood was sampled for analysis of arterialized pressure in oxygen, and venous blood was drawn for analysis of plasma lactate concentrations and hemorheological parameters. Lactate influxes into RBCs were measured at three labeled [U-14C]lactate concentrations (1.6, 8.1, and 41 mM) on venous blood sampled at rest. The EIH subjects had higher maximal oxygen uptake than non-EIH (P < 0.05). Total lactate influx was significantly higher in RBCs from EIH compared with non-EIH subjects at 8.1 mM (1,498.1 +/- 87.8 vs. 1,035.9 +/- 114.8 nmol.ml(-1).min(-1); P < 0.05) and 41 mM (2,562.0 +/- 145.0 vs. 1,618.1 +/- 149.4 nmol.ml(-1).min(-1); P < 0.01). Monocarboxylate transporter-1-mediated lactate influx was also higher in EIH at 8.1 mM (P < 0.05) and 41 mM (P < 0.01). The drop in arterial oxygen partial pressure was negatively correlated with total lactate influx measured at 8.1 mM (r = -0.82, P < 0.05) and 41 mM (r = -0.84, P < 0.05) in the two groups together. Plasma lactate concentrations and hemorheological data were similar in the two groups at rest and at the end of exercise. The results showed higher monocarboxylate transporter-1-mediated lactate influx in the EIH subjects and suggested that EIH could modify lactate influx into erythrocyte. However, higher lactate influx in EIH subjects was not accompanied by an increase in RBC rigidity. |
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Authors:
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Philippe Connes; Didier Bouix; Guillaume Py; Corinne Caillaud; Pascale Kippelen; Jean-Frédéric Brun; Alain Varray; Christian Prefaut; Jacques Mercier |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article Date: 2004-04-30 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 97 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-08-30 Completed Date: 2005-02-10 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 1053-8 Citation Subset: IM |
Affiliation:
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EA 2991 Sport, Performance et Santé, Faculté des Sciences du Sport, Université de Montpellier, 34295 Montpellier, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological Adult Anoxia / blood*, etiology, physiopathology* Blood Viscosity Erythrocytes / metabolism* Exercise Test Hematocrit Hemorheology / methods Humans Lactic Acid / blood* Male Monocarboxylic Acid Transporters / chemistry* Oxygen Consumption Physical Endurance* Physical Exertion* Sports Symporters / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Monocarboxylic Acid Transporters; 0/Symporters; 0/monocarboxylate transport protein 1; 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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