| Does exercise have deleterious consequences for the lungs of patients with chronic heart failure? | |
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MedLine Citation:
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PMID: 19008089 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Changes in lung function in patients with chronic heart failure (CHF), usually reported at rest, may be exacerbated during exercise and induce post-exercise effects. We investigated the hypothesis that post-exercise induced changes in lung function in CHF patients are due to the consequences of left atrial overload. Twenty-one CHF patients and six healthy subjects (Ctrl) participated in this study. Transfer lung capacity for carbon monoxide (T(LCO)) and maximal expiratory flows (V (max)) were measured before a maximal exercise test and 1h, 2h and 20h afterwards. CHF patients were divided in two groups according to their ventilatory response to the maximal exercise test (V(E) vs. V(CO(2)) relationship slopes above or below 34, i.e., CHF>34 and CHF<34). Compared with the Ctrl group, in CHF groups resting T(LCO) and V(max) were lower. After exercise, further changes in T(LCO) and V(max) were observed in CHF>34. T(LCO) per unit volume (K(CO)) was increased 1h post-exercise while maximal expiratory flow between 25 and 75% of forced vital capacity was decreased 2h and 20h post-exercise. We observed a negative correlation between the delta T(LCO) 1h post-exercise from rest and the delta T(LCO) 2h post-exercise from rest. The decreases in pulmonary V(max) we observed well after exercise following increases in K(CO) in patients with high ventilatory response to exercise (CHF>34) might indicate bronchial congestion resulting from increased left atrial pressure during exercise. We propose that endurance training should be prescribed cautiously for these patients. |
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Authors:
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Manuel Roulaud; Erwan Donal; Pascale Raud-Raynier; André Denjean; Claire de Bisschop |
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Publication Detail:
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Type: Journal Article Date: 2008-11-13 |
Journal Detail:
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Title: Respiratory medicine Volume: 103 ISSN: 1532-3064 ISO Abbreviation: Respir Med Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-02-10 Completed Date: 2009-06-04 Revised Date: 2009-07-15 |
Medline Journal Info:
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Nlm Unique ID: 8908438 Medline TA: Respir Med Country: England |
Other Details:
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Languages: eng Pagination: 393-400 Citation Subset: IM |
Affiliation:
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Laboratoire des Adaptations Physiologiques aux Activités Physiques, Faculté des Sciences du Sport, UPRES EA, Poitiers, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Analysis of Variance Carbon Monoxide / metabolism Case-Control Studies Chronic Disease Exercise Test / adverse effects*, contraindications, methods Female Forced Expiratory Volume Heart Failure / metabolism, physiopathology*, therapy Humans Linear Models Lung / metabolism, physiopathology* Male Maximal Expiratory Flow Rate Middle Aged Pulmonary Diffusing Capacity Vital Capacity |
| Chemical | |
Reg. No./Substance:
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630-08-0/Carbon Monoxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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