Document Detail

Does eradication of Helicobacter pylori reduce hypergastrinaemia during long term therapy with proton pump inhibitors?
MedLine Citation:
PMID:  12762431     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To evaluate the effect of Helicobacter pylori (Hp) eradication therapy on blood gastrin levels in long-term PPI users, since proton pump inhibitors (PPIs) and Helicobacter pylori (Hp) are major causes of hypergastrinaemia. DESIGN: A prospective study. SUBJECTS: Twenty seven Hp (+) patients enrolled in the study. Twenty were given eradication treatment (ET group), and the rest were given symptomatic treatment (ST group). Those who remained Hp (+) after eradication therapy were also added into the ST group. Lansoprazol 30 mg/day was given to both groups for three months thereafter. RESULTS: Fasting and non-fasting blood gastrin levels (FGL and NFGL) were measured initially and one month and four months after treatment. At the end of fourth month, FGL was significantly higher than both initial and first month level (p < 0.01) in the ST group. NFGL in this group did not change significantly (p > 0.05) after eradication therapy. In the ET group, FGL was significantly higher in the fourth month than the first month (p < 0.001) and than the initial level (p < 0.05). NFGL was higher, but not statistically in the fourth month than in the first month (p > 0.05) and significantly lower than the initial level (p < 0.05) in this group. CONCLUSION: We suggest that testing for Hp positivity and treating it if detected would be an appropriate approach to avoid hypergastrinaemia, especially in candidate patients for long term PPI treatment.
A K Gürbüz; A M Ozel; Y Yazgan; A Günay; T Polat
Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  East African medical journal     Volume:  80     ISSN:  0012-835X     ISO Abbreviation:  East Afr Med J     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-05-23     Completed Date:  2003-07-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372766     Medline TA:  East Afr Med J     Country:  Kenya    
Other Details:
Languages:  eng     Pagination:  150-3     Citation Subset:  IM    
Department of Gastroenterology, Gülhane Military Medical Academy, Haydarpasa Training Hospital, Istanbul, Turkey.
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MeSH Terms
Anti-Ulcer Agents / therapeutic use*
Esophagitis / complications,  drug therapy
Fasting / blood
Gastrins / blood*,  drug effects*
Helicobacter Infections / blood,  complications,  drug therapy*
Helicobacter pylori*
Middle Aged
Peptic Ulcer / complications,  drug therapy
Prospective Studies
Proton Pumps / antagonists & inhibitors*
Reg. No./Substance:
0/Anti-Ulcer Agents; 0/Gastrins; 0/Proton Pumps

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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