Document Detail


Does enteral nutrition of dietary polyunsaturated fatty acids promote oxidative stress and tumour growth in ductal pancreatic cancer? Experimental trial in Syrian Hamster.
MedLine Citation:
PMID:  16226437     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Type and composition of dietary fat intake is supposed to play an important role in carcinogenesis. Thus we investigated the effects of n-3, n-6 and n-9 polyunsaturated fatty acids (PUFA) on oxidative stress (lipidperoxidation) and tumour growth in ductal pancreatic cancer. METHODS: Ninety male hamsters were randomized into 6 groups (gr.) (n=15) and allocated to 3 main dietary categories: gr. 1 and 2 received a standard high fat diet (SHF, rich in n-6 PUFA), while gr. 3 and 4 were fed with a diet containing a mixture of n-3, n-6 and n-9 PUFA (SMOF) and gr. 5 and 6 had free access to a diet rich in n-3 PUFA (FISH-OIL). Gr. 1, 3 and 5 received weekly subcutaneous (s.c.) injections of 10 mg N-nitrosobis-2-oxypropylamine (BOP)/kg body weight in order to induce ductal pancreatic adenocarcinoma. Healthy control gr. 2, 4 and 6 were treated with 0.5 ml 0.9% sodium chloride s.c. After 32 weeks all animals were sacrificed. Removed pancreata were weighed and analysed histologically and biochemically. Activities of glutathionperoxidase (GSH-Px), superoxiddismutase (SOD) and levels of lipidperoxidation were measured in samples of pancreatic carcinoma as well as in tumour-free pancreatic tissue. RESULTS: While different diets did not significantly alter the overall incidence of histologically proven pancreatic adenocarcinoma, the number of macroscopically visible tumours was decreased in the FISH-OIL-gr. CONCLUSION: Different diets did not significantly influence the incidence of histologically proven pancreatic adenocarcinoma. However, administration of a diet rich in n-3 PUFA (FISH-OIL) resulted in a decrease of macroscopically visible tumours, thus indicating its beneficial effects in respect to attenuation of tumour growth.
Authors:
J I Gregor; I Heukamp; M Kilian; C Kiewert; I Schimke; G Kristiansen; M K Walz; C A Jacobi; F A Wenger
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2005-10-13
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  74     ISSN:  0952-3278     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-12     Completed Date:  2006-02-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  67-74     Citation Subset:  IM    
Affiliation:
Clinic of General, Visceral, Vascular and Thoracic Surgery, Charité Campus Mitte, Humbold-University of Berlin, 10117 Berlin, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carcinogens / administration & dosage,  toxicity
Carcinoma, Pancreatic Ductal / etiology,  mortality,  pathology*
Cricetinae
Dietary Fats, Unsaturated / pharmacology*
Docosahexaenoic Acids / analysis,  pharmacology
Eicosapentaenoic Acid / analysis,  pharmacology
Enteral Nutrition*
Fatty Acids, Unsaturated / pharmacology
Fish Oils / chemistry,  pharmacology
Glutathione Peroxidase / metabolism
Linoleic Acid / analysis,  pharmacology
Male
Mesocricetus
Nitrosamines / administration & dosage,  toxicity
Oleic Acid / analysis,  pharmacology
Oxidative Stress / drug effects*
Pancreas / drug effects,  metabolism,  pathology
Pancreatic Neoplasms / etiology,  mortality,  pathology*
Plant Oils / chemistry,  pharmacology
Random Allocation
Soybean Oil / chemistry,  pharmacology
Superoxide Dismutase / metabolism
Survival Rate
Thiobarbituric Acid Reactive Substances / metabolism
Triglycerides / chemistry,  pharmacology
Chemical
Reg. No./Substance:
0/Carcinogens; 0/Dietary Fats, Unsaturated; 0/Fatty Acids, Unsaturated; 0/Fish Oils; 0/Nitrosamines; 0/Plant Oils; 0/Thiobarbituric Acid Reactive Substances; 0/Triglycerides; 112-80-1/Oleic Acid; 1553-41-9/Eicosapentaenoic Acid; 2197-37-7/Linoleic Acid; 25167-62-8/Docosahexaenoic Acids; 60599-38-4/nitrosobis(2-oxopropyl)amine; 8001-22-7/Soybean Oil; 8001-25-0/olive oil; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase

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